{"title":"流感病毒神经氨酸酶/唾液酸酶:其特征，命名，活性测量，动力学，作为治疗剂的抑制剂","authors":"José Antonio Cabezas Fernández del Campo","doi":"10.53519/analesranf.2022.88.05.07","DOIUrl":null,"url":null,"abstract":"The main characteristics of neuraminidase / sialidase from Influenza Virus and its peculiar nomenclature are described, as well as two new, sensitive and simple procedures (fluorometric and by luminiscence) for measuring neuraminidase activity, which have been used at the Department of Biochemistry and Molecular Biology of the University of Salamanca (Prof. J. A. Cabezas). The kinetics of neuraminidase of three A and three B Influenza Virus Strains, and the result of the comparison of biological and physical properties of human and animal origin (pig and duck) Virus Strains, belonging to the same subtype A(H1N1), are described. Finally, the advantages and risks for the use as therapeutic agents against Influenza of the Influenza Virus neuraminidase inhibitors Zanamivir, Oseltamivir and Peramivir are discussed.\n\nKeywords: neuraminidase / sialidase; influenza virus; inhibitors","PeriodicalId":50795,"journal":{"name":"Anales De La Real Academia Nacional De Farmacia","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neuraminidase / sialidase from influenza virus: its characteristics, nomenclature, measuring of activity, kinetics, inhibitors as therapeutic agents\",\"authors\":\"José Antonio Cabezas Fernández del Campo\",\"doi\":\"10.53519/analesranf.2022.88.05.07\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The main characteristics of neuraminidase / sialidase from Influenza Virus and its peculiar nomenclature are described, as well as two new, sensitive and simple procedures (fluorometric and by luminiscence) for measuring neuraminidase activity, which have been used at the Department of Biochemistry and Molecular Biology of the University of Salamanca (Prof. J. A. Cabezas). The kinetics of neuraminidase of three A and three B Influenza Virus Strains, and the result of the comparison of biological and physical properties of human and animal origin (pig and duck) Virus Strains, belonging to the same subtype A(H1N1), are described. Finally, the advantages and risks for the use as therapeutic agents against Influenza of the Influenza Virus neuraminidase inhibitors Zanamivir, Oseltamivir and Peramivir are discussed.\\n\\nKeywords: neuraminidase / sialidase; influenza virus; inhibitors\",\"PeriodicalId\":50795,\"journal\":{\"name\":\"Anales De La Real Academia Nacional De Farmacia\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Anales De La Real Academia Nacional De Farmacia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.53519/analesranf.2022.88.05.07\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anales De La Real Academia Nacional De Farmacia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.53519/analesranf.2022.88.05.07","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
Neuraminidase / sialidase from influenza virus: its characteristics, nomenclature, measuring of activity, kinetics, inhibitors as therapeutic agents
The main characteristics of neuraminidase / sialidase from Influenza Virus and its peculiar nomenclature are described, as well as two new, sensitive and simple procedures (fluorometric and by luminiscence) for measuring neuraminidase activity, which have been used at the Department of Biochemistry and Molecular Biology of the University of Salamanca (Prof. J. A. Cabezas). The kinetics of neuraminidase of three A and three B Influenza Virus Strains, and the result of the comparison of biological and physical properties of human and animal origin (pig and duck) Virus Strains, belonging to the same subtype A(H1N1), are described. Finally, the advantages and risks for the use as therapeutic agents against Influenza of the Influenza Virus neuraminidase inhibitors Zanamivir, Oseltamivir and Peramivir are discussed.
Keywords: neuraminidase / sialidase; influenza virus; inhibitors
期刊介绍：
The Anales de la Real Academia Nacional de Farmacia� embraces all aspects of pharmaceutical sciences and is a quarterly journal that publishes basic and applied research on pharmaceutical sciences and related areas. It is a medium for reporting selected original and significant contributions to new pharmaceutical knowledge.
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