2型糖尿病患者对牙齿不满意与心血管疾病风险增加有关

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-10-01 DOI:10.1016/j.deman.2022.100090

Edvin Ström , Tobias Rudholm Feldreich , Johan Ärnlöv , Carl Johan Östgren , Fredrik H Nystrom , Magnus O Wijkman

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引用次数: 0

摘要

背景和目的2型糖尿病(T2D)患者牙齿健康状况不佳与心血管事件风险增加有关。人们对自我感知的牙齿健康和心血管风险知之甚少。我们这项研究的目的是调查这种关联。方法在2005年至2008年期间招募瑞典初级保健的t2dm患者。基线时采用问卷方式评估牙齿满意度。本研究的主要心血管不良事件(MACE)为因心肌梗死、中风或心血管死亡而住院。采用Cox回归模型。结果761例受试者中，601例数据完整。92例发生mace(中位随访时间:11.6年)。对牙齿满意的患者(n = 458)有61次(每100人年1.2次)，而对牙齿不满意的患者(n = 143)有31次(每100人年2.2次)。对牙齿不满意与MACE风险增加相关，与年龄、性别和CRP水平无关(HR 1.85, 95% CI 1.20 - 2.86)。结论在T2D患者中，对牙齿的不满意与MACE发生的风险增加相关，可作为MACE发生的危险标志。

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Dissatisfaction with teeth in type 2 diabetes is associated with increased risk of cardiovascular disease

Background and aim

Poor dental health status has been linked to increased risk of cardiovascular events in type 2 diabetes (T2D). Less is known about self-perceived dental health and cardiovascular risk. Our aim with this study was to investigate this association.

Methods

Recruitment of T2D patients took place between 2005 and 2008 in Swedish primary care. Teeth satisfaction was assessed by questionnaire at baseline. The major adverse cardiovascular events (MACE) in this study were hospitalization due to myocardial infarction, stroke or cardiovascular death. Cox regression models were used.

Results

Out of 761 participants 601 had complete data. Ninety-two MACEs occurred (median follow-up time: 11.6 years). Those satisfied with their teeth (n = 458) had 61 events (1.2 events per 100 person-years), while those dissatisfied with teeth (n = 143) had 31 events (2.2 events per 100 person-years). Dissatisfaction with teeth was associated with an increased risk of MACE independent of age, sex and levels of CRP (HR 1.85, 95% CI 1.20 – 2.86).

Conclusions

In patients with T2D, dissatisfaction with teeth was associated with increased risk of MACE and may be considered as a marker of risk.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.