辅助生殖技术项目中BRCA1/2基因突变携带者排卵刺激的致癌潜力

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Russian Open Medical Journal Pub Date : 2022-03-20 DOI:10.15275/rusomj.2022.0116

Lidia A. Klyukina, E. A. Sosnova, A. Ishchenko

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引用次数: 0

摘要

BRCA1/2基因突变是癌症和癌症发生的一个基本和独立的危险因素。BRCA1/2基因突变携带者的不孕治疗对患癌症风险的具体影响尚不清楚，需要进行全面调查。在这篇综述中，我们分析了BRCA1/2突变携带者的不孕治疗与卵巢和乳腺癌症风险之间的可能关系的已发表资料。

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Carcinogenic Potential Of Ovulation Stimulation In BRCA1/2 Gene Mutation Carriers In Assisted Reproductive Technology Programs

Mutations of the BRCA1/2 genes constitute a fundamental and independent risk factor in the genesis of both breast cancer and ovarian cancer. The specifics of the infertility treatment effect on the risk of developing cancer in carriers of mutations in the BRCA1/2 genes remain unclear and require a comprehensive investigation. In this review, we analyzed published sources on the possible relationship between the infertility treatment and the risk of ovarian and breast cancer in BRCA1/2 mutation carriers.

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来源期刊

Russian Open Medical Journal MEDICINE, GENERAL & INTERNAL-

CiteScore

0.90

自引率

0.00%

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期刊介绍： Russian Open Medical Journal (RusOMJ) (ISSN 2304-3415) is an international peer reviewed open access e-journal. The website is updated quarterly with the RusOMJ’s latest original research, clinical studies, case reports, reviews, news, and comment articles. This Journal devoted to all field of medicine. All the RusOMJ’s articles are published in full on www.romj.org with open access and no limits on word counts. Our mission is to lead the debate on health and to engage, inform, and stimulate doctors, researchers, and other health professionals in ways that will improve outcomes for patients. The RusOMJ team is based mainly in Saratov (Russia), although we also have editors elsewhere in Russian and in other countries.