Aducanumab试验出现但不参与

IF 8.5 3区 医学 Q1 CLINICAL NEUROLOGY Jpad-Journal of Prevention of Alzheimers Disease Pub Date : 2022-01-01 DOI:10.14283/jpad.2022.37
L S Schneider
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引用次数: 0

摘要

如果一开始你没有成功,尝试,尝试(试试?)再把那该死的手稿发表就按你所希望的方式(1)。这就是24作者之后从JAMA拒绝或修改和重新提交,可能来自《新英格兰医学杂志》上的《美国医学会杂志》之前,如果不是后来另一个杂志(只是猜测基于Axios报告和JAMA的时机提交https://www.axios.com/biogen jamaaduhelm -临床试验结果发布- fc7c2876 a684 - 4 - bfc8462 - 4165 f57d735a.html)。Emerge(302)和Engage(301)的手稿似乎已经被扣留了两年多,因为Biogen和学术作者不愿回应或遵守审稿人和编辑的要求。在JPAD轮到它之前,手稿可能已经被6到12位审稿人审稿了。不幸的是,这个已发表的版本几乎没有经过严格审查的证据(1)。到处都有辩护的语气,但几乎没有证据表明,在陈述、实施和试验结果中,经过深思熟虑或不确定。(也许值得注意的是,他们的结构化摘要保留了JAMA对提交手稿的独特风格,并在修改后的手稿发表时重新格式化(https://jamanetwork.com/ journals/ JAMA /pages/ instructions-forauthors #SecAb stractsforReportsofOriginalData)。显然,作者希望完全控制他们的信息,而不必承认他们的试验、结果和推断的实质性局限性。他们想要传达的信息是:高剂量aducanumab达到了“预先设定的”主要和次要终点;显示“潜在疾病病理”生物标志物的减少与临床衰退减缓之间的关联;并且具有“临床意义”的效果。坦率地说,这在很多层面上都是错误的。
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Editorial: Aducanumab Trials EMERGE But Don't ENGAGE.
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来源期刊
自引率
7.80%
发文量
85
期刊介绍: The JPAD « Journal of Prevention of Alzheimer’Disease » will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including : neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes. JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.
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