Screening of bone cements loaded with antituberculosis drugs: preparation and determination of physical properties

Objective To explore the physical properties of bone cements loaded with atituberculosis drugs. Methods We mixed ten drugs with four bone cements by 1.5 g∶40.0 g and 2.5 g∶40.0 g, 400 modules of 80 groups were maded according to the ISO. The control group mixed bone cements with their liquid monomer, 20 modules of 4 groups were maded. The physical properties were measured respectively. Results Group 1.5 g and 2.5 g of E, Z, S, C, A, M mixed with Palacos R, Palacos MV, Simplex P, the average dough time, solidification time, maximum temperature and mechanical strength were all meet ISO, and hardened in 20 minutes after mixing. Group 1.5 g and 2.5 g of R, H, Rt, and P mixed with the bone cements above, the average dough time, solidification time were all >ISO, the average maximum temperature was 0.05) between the four kinds of bone cements. The flexural strength and flexural modulus (P<0.01) were different. The physical properties of Palacos R and Simplex P bone cements meet ISO. The flexural strength and flexural modulus of CEMEX XL bone cement were