严重急性呼吸系统综合征冠状病毒2型在炎症性肠病患者中的高患病率和可溶性血管紧张素转化酶2的作用。

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM Archives of Physiology and Biochemistry Pub Date : 2024-06-01 Epub Date: 2022-05-26 DOI:10.1080/13813455.2022.2080228

Shabnam Shahrokh, Shaghayegh Baradaran Ghavami, Hamid Asadzadeh Aghdaei, Tommaso Lorenzo Parigi, Maryam Farmani, Silvio Danese, Nasser Ebrahimi Daryani, Hassan Vossoughinia, Hedieh Balaii, Foroogh Alborzi, Seyed Mobin Khoramjoo, Binazir Khanabadi, Ali Seyed Salehi, Ali Bastani, Mohsen Sharifi, Mohammad Taghi Safari, Habib Malekpour, Ghazal Sherkat, Malihe Saberafsharian, Mohammad Bagher Miri, Seyed Hamid Moosavi, Fakhrosadat Anaraki, Ehsan Nazemalhosseini-Mojarad, Seyed Reza Mohebbi, Sajad Shojaie, Mohamad Amin Pourhoseingholi, Mohammad Reza Zali

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引用次数: 0

摘要

背景:研究发现炎症性肠病(IBD)患者肠道中血管紧张素转换酶2 (ACE2)的表达较高，从而增加对COVID-19感染的易感性。目的:本研究报告了大型IBD患者中COVID-19感染的结局。我们比较了伴有和不伴有IBD的covid - 19患者的血清ACE和IFN-α水平。我们进行了一项横断面回顾性多中心研究。方法:研究人员招募了2020年6月至11月在伊朗6个医疗中心接受SARS-COV-2筛查的IBD患者。采集血样检测COVID-19 IgM、IgG、血清sACE2、sACE1、干扰素α水平，不论有无可疑症状均进行分子检测。结果:共纳入534例IBD患者。其中109例(20.0%)可检测到针对SARS-CoV-2的IgG和IgM。IBD患者的sACE2水平高于对照组，而各组间ace1和IFN-α水平相似。

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High prevalence of SARS-Coronavirus-2 in patients with inflammatory bowel disease and the role of soluble angiotensin converting Enzyme2.

Context: Patients with inflammatory bowel disease (IBD) were found to have the higher intestinal expression of Angiotensin-Converting Enzyme2 (ACE2) that could consequently increase susceptibility to COVID-19 infection.Objective: This study reports the outcomes of COVID-19 infection in a large cohort of IBD patients. We compare levels of serum ACE and IFN-α between COVID19 patients with and without IBD. We performed a cross-sectional retrospective multicenter study.Methods: We enrolled patients with IBD screened for SARS-COV-2 in six medical centres in Iran from June to November 2020. The blood samples were drawn to measure COVID-19 IgM and IgG, and serum levels of sACE2, sACE1, and interferon-α, regardless of suspicious symptoms have done the molecular test.Results: A total of 534 IBD patients were included in the study. Of these, 109 (20.0%) cases had detectable IgG and IgM against SARS-CoV-2. sACE2 levels were higher in IBD patients than controls, whereas ACE1and IFN-α levels were similar among groups.

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.