抗肿瘤坏死因子诱导的局灶性肌炎

IF 0.4 Q3 MEDICINE, GENERAL & INTERNAL Proceedings of Singapore Healthcare Pub Date : 2022-06-01 DOI:10.1177/20101058221147755
A. Masnammany, Wendy Lau, P. Wong, N. Manolios
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引用次数: 1

摘要

肿瘤坏死因子抑制剂(TNFis)会引发自身抗体的形成,在一小部分患者中,会导致症状性自身免疫性疾病,包括多发性肌炎和皮肌炎。局灶性肌炎表现为局部肌肉疼痛,根据磁共振成像(MRI)、肌电图(EMG)和肌肉组织病理学进行诊断。我们报告了第一例使用英夫利昔单抗治疗的溃疡性结肠炎患者左大腿TNFi诱导的局灶性肌炎。一位30岁的女士出现左大腿疼痛,没有其他全身表现或肌肉无力。免疫学图谱显示抗核抗体(ANA)阳性,抗ds-DNA高滴度,抗Mi-2无任何系统性红斑狼疮或皮肌炎特征。TNFi的终止和糖皮质激素的开始导致肌炎的消退。
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Anti tumor necrosis factor induced focal myositis
Tumour necrosis factor inhibitors (TNFis) can trigger autoantibody formation and, in a small proportion of patients, result in symptomatic autoimmune diseases, including polymyositis and dermatomyositis. Focal myositis presents with localized muscle pain and is diagnosed based on magnetic resonance imaging (MRI), electromyography (EMG) and muscle histopathology. We report the first case of TNFi-induced focal myositis in the left thigh of a patient with ulcerative colitis on infliximab. A 30-year-old lady presented with left thigh pain with no other systemic manifestation or muscle weakness. The immunology profile showed positivity of antinuclear antibody (ANA), high titre of anti-ds-DNA, and anti-Mi-2 without any features of systemic lupus erythematosus or dermatomyositis. Discontinuation of the TNFi and commencement of glucocorticoids resulted in the resolution of the myositis.
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来源期刊
Proceedings of Singapore Healthcare
Proceedings of Singapore Healthcare MEDICINE, GENERAL & INTERNAL-
CiteScore
0.90
自引率
0.00%
发文量
42
审稿时长
15 weeks
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