CTLA4 c.49A > G (rs231775;p.Thr17Ala)基因变异与肝细胞癌和胃癌风险的meta分析和meta回归

IF 0.8 Q4 GENETICS & HEREDITY Meta Gene Pub Date : 2022-02-01 DOI:10.1016/j.mgene.2021.100999
Akram Abbas El Awady , Rami M. Elshazli , Ahmed Akram El Awady , Abdelaziz Elgaml , Ahmed K. Khalifa , Ahmad Settin
{"title":"CTLA4 c.49A > G (rs231775;p.Thr17Ala)基因变异与肝细胞癌和胃癌风险的meta分析和meta回归","authors":"Akram Abbas El Awady ,&nbsp;Rami M. Elshazli ,&nbsp;Ahmed Akram El Awady ,&nbsp;Abdelaziz Elgaml ,&nbsp;Ahmed K. Khalifa ,&nbsp;Ahmad Settin","doi":"10.1016/j.mgene.2021.100999","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>Various reports have examined the contribution of the <em>CTLA4 c.49A</em> <em>&gt;</em> <em>G (rs231775; p.Thr17Ala)</em><span> gene variant with different cancerous disorders. This meta-analysis was executed to further probe into the involvement of this missense variant with the susceptibility for hepatocellular carcinoma (HCC) and gastric cancer (GC).</span></p></div><div><h3>Methodology</h3><p>Following a wide-based scrutinized search of the internet done by three independent researchers for the contribution of the <em>CTLA4 c.49A</em> <em>&gt;</em> <em>G (rs231775; p.Thr17Ala)</em><span> variant with the cancer risk up to February 2021, only 16 case-control studies were found relevant and usable to the analysis out of 575 total retrieved reports. Multiple genetic models were checked for the proposed association through the computation of the odds ratio (OR) in addition to their 95% confidence intervals (95%CIs). Stratification and regression analysis was also carried out for the analyzed reports based on their geographical distributions, genotyping techniques, source of cancer-free controls, genetic equilibrium within cancer-free controls, and quality score. In addition, trial sequential analysis (TSA) was applied to test for the adequacy of the total sample size.</span></p></div><div><h3>Results</h3><p>This meta-analysis has included 4320 HCC and GC patients in conjunction with 6601 cancer-free controls. This work disclosed a significant association for the <em>CTLA4 c.49A</em> <em>&gt;</em> <em>G (rs231775; p.Thr17Ala)</em> variant with HCC among overall subjects tested by the recessive model [OR = 1.235, 95% CI = 1.050–1.453, <em>P-value</em> = 0.011]. Similarly, an elevated risk of GC was noticed associated with this variant within the overall subjects tested by the allelic model [OR = 1.225, 95% CI = 1.070–1.401, <em>P-value</em> = 0.003], and dominant model [OR = 1.352, 95% CI = 1.081–1.691, <em>P-value</em> = 0.008]. Furthermore, the stratification analysis showed a verification of correlation for this variant with HCC in Asian subjects under the recessive model, while the association was observed to be significant with GC in Asian and Caucasian patients under the dominant model. TSA confirmed that this work had significant findings noting that the collective <em>Z</em>-curve spanned the examining borderlines prior to attaining sample size confirming the acceptability of the study sample size.</p></div><div><h3>Conclusion</h3><p><em>The CTLA4 c.49A</em> <em>&gt;</em> <em>G (rs231775; p.Thr17Ala)</em><span> gene variant could be considered as an actual risk factor for the susceptibility of HCC and GC warranting efficient and adequate genetic counseling for this gene variant carriers.</span></p></div>","PeriodicalId":38190,"journal":{"name":"Meta Gene","volume":"31 ","pages":"Article 100999"},"PeriodicalIF":0.8000,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Association of CTLA4 c.49A > G (rs231775; p.Thr17Ala) gene variant with the risk of hepatocellular carcinoma and gastric cancer: A meta-analysis and meta-regression\",\"authors\":\"Akram Abbas El Awady ,&nbsp;Rami M. Elshazli ,&nbsp;Ahmed Akram El Awady ,&nbsp;Abdelaziz Elgaml ,&nbsp;Ahmed K. Khalifa ,&nbsp;Ahmad Settin\",\"doi\":\"10.1016/j.mgene.2021.100999\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>Various reports have examined the contribution of the <em>CTLA4 c.49A</em> <em>&gt;</em> <em>G (rs231775; p.Thr17Ala)</em><span> gene variant with different cancerous disorders. This meta-analysis was executed to further probe into the involvement of this missense variant with the susceptibility for hepatocellular carcinoma (HCC) and gastric cancer (GC).</span></p></div><div><h3>Methodology</h3><p>Following a wide-based scrutinized search of the internet done by three independent researchers for the contribution of the <em>CTLA4 c.49A</em> <em>&gt;</em> <em>G (rs231775; p.Thr17Ala)</em><span> variant with the cancer risk up to February 2021, only 16 case-control studies were found relevant and usable to the analysis out of 575 total retrieved reports. Multiple genetic models were checked for the proposed association through the computation of the odds ratio (OR) in addition to their 95% confidence intervals (95%CIs). Stratification and regression analysis was also carried out for the analyzed reports based on their geographical distributions, genotyping techniques, source of cancer-free controls, genetic equilibrium within cancer-free controls, and quality score. In addition, trial sequential analysis (TSA) was applied to test for the adequacy of the total sample size.</span></p></div><div><h3>Results</h3><p>This meta-analysis has included 4320 HCC and GC patients in conjunction with 6601 cancer-free controls. This work disclosed a significant association for the <em>CTLA4 c.49A</em> <em>&gt;</em> <em>G (rs231775; p.Thr17Ala)</em> variant with HCC among overall subjects tested by the recessive model [OR = 1.235, 95% CI = 1.050–1.453, <em>P-value</em> = 0.011]. Similarly, an elevated risk of GC was noticed associated with this variant within the overall subjects tested by the allelic model [OR = 1.225, 95% CI = 1.070–1.401, <em>P-value</em> = 0.003], and dominant model [OR = 1.352, 95% CI = 1.081–1.691, <em>P-value</em> = 0.008]. Furthermore, the stratification analysis showed a verification of correlation for this variant with HCC in Asian subjects under the recessive model, while the association was observed to be significant with GC in Asian and Caucasian patients under the dominant model. TSA confirmed that this work had significant findings noting that the collective <em>Z</em>-curve spanned the examining borderlines prior to attaining sample size confirming the acceptability of the study sample size.</p></div><div><h3>Conclusion</h3><p><em>The CTLA4 c.49A</em> <em>&gt;</em> <em>G (rs231775; p.Thr17Ala)</em><span> gene variant could be considered as an actual risk factor for the susceptibility of HCC and GC warranting efficient and adequate genetic counseling for this gene variant carriers.</span></p></div>\",\"PeriodicalId\":38190,\"journal\":{\"name\":\"Meta Gene\",\"volume\":\"31 \",\"pages\":\"Article 100999\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2022-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Meta Gene\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S221454002100150X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"GENETICS & HEREDITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Meta Gene","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S221454002100150X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 4

摘要

各种报告都审查了CTLA4 c.49A >G (rs231775;p.Thr17Ala)基因变异与不同的癌症疾病有关。本荟萃分析旨在进一步探讨这种错义变异与肝细胞癌(HCC)和胃癌(GC)易感性的关系。方法:三位独立研究人员在互联网上进行了广泛的仔细搜索,为CTLA4 c.49A >G (rs231775;到2021年2月,p.s thr17ala)变异与癌症风险的关系,在575份检索到的报告中,只有16份病例对照研究被发现与分析相关并可用。通过计算比值比(OR)和95%置信区间(95% ci)来检查多个遗传模型是否存在关联。根据分析报告的地理分布、基因分型技术、无癌对照来源、无癌对照内的遗传平衡和质量评分对分析报告进行分层和回归分析。此外,采用试验序列分析(TSA)来检验总样本量的充分性。该荟萃分析纳入了4320例HCC和GC患者以及6601例无癌对照。这项工作揭示了CTLA4 c.49A >G (rs231775;隐性模型检测的所有受试者中p.s thr17ala变异伴HCC [OR = 1.235, 95% CI = 1.050-1.453, p值= 0.011]。同样,在等位基因模型[OR = 1.225, 95% CI = 1.070-1.401, p值= 0.003]和显性模型[OR = 1.352, 95% CI = 1.081-1.691, p值= 0.008]测试的所有受试者中,GC风险升高也与该变异相关。此外,分层分析显示,在隐性模型下,该变异与亚洲受试者的HCC存在相关性,而在显性模型下,该变异与亚洲和高加索患者的GC存在显著相关性。TSA确认这项工作有重要的发现,注意到在获得样本量之前,集体z曲线跨越了检查边界,确认了研究样本量的可接受性。结论CTLA4 c.49A >G (rs231775;p.Thr17Ala)基因变异可以被认为是HCC和GC易感性的实际危险因素,需要对该基因变异携带者进行有效和充分的遗传咨询。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Association of CTLA4 c.49A > G (rs231775; p.Thr17Ala) gene variant with the risk of hepatocellular carcinoma and gastric cancer: A meta-analysis and meta-regression

Objective

Various reports have examined the contribution of the CTLA4 c.49A > G (rs231775; p.Thr17Ala) gene variant with different cancerous disorders. This meta-analysis was executed to further probe into the involvement of this missense variant with the susceptibility for hepatocellular carcinoma (HCC) and gastric cancer (GC).

Methodology

Following a wide-based scrutinized search of the internet done by three independent researchers for the contribution of the CTLA4 c.49A > G (rs231775; p.Thr17Ala) variant with the cancer risk up to February 2021, only 16 case-control studies were found relevant and usable to the analysis out of 575 total retrieved reports. Multiple genetic models were checked for the proposed association through the computation of the odds ratio (OR) in addition to their 95% confidence intervals (95%CIs). Stratification and regression analysis was also carried out for the analyzed reports based on their geographical distributions, genotyping techniques, source of cancer-free controls, genetic equilibrium within cancer-free controls, and quality score. In addition, trial sequential analysis (TSA) was applied to test for the adequacy of the total sample size.

Results

This meta-analysis has included 4320 HCC and GC patients in conjunction with 6601 cancer-free controls. This work disclosed a significant association for the CTLA4 c.49A > G (rs231775; p.Thr17Ala) variant with HCC among overall subjects tested by the recessive model [OR = 1.235, 95% CI = 1.050–1.453, P-value = 0.011]. Similarly, an elevated risk of GC was noticed associated with this variant within the overall subjects tested by the allelic model [OR = 1.225, 95% CI = 1.070–1.401, P-value = 0.003], and dominant model [OR = 1.352, 95% CI = 1.081–1.691, P-value = 0.008]. Furthermore, the stratification analysis showed a verification of correlation for this variant with HCC in Asian subjects under the recessive model, while the association was observed to be significant with GC in Asian and Caucasian patients under the dominant model. TSA confirmed that this work had significant findings noting that the collective Z-curve spanned the examining borderlines prior to attaining sample size confirming the acceptability of the study sample size.

Conclusion

The CTLA4 c.49A > G (rs231775; p.Thr17Ala) gene variant could be considered as an actual risk factor for the susceptibility of HCC and GC warranting efficient and adequate genetic counseling for this gene variant carriers.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Meta Gene
Meta Gene Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
1.10
自引率
0.00%
发文量
20
期刊介绍: Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.
期刊最新文献
Severity of coronavirus disease 19: Profile of inflammatory markers and ACE (rs4646994) and ACE2 (rs2285666) gene polymorphisms in Iraqi patients MicroRNAs based regulation of cytokine regulating immune expressed genes and their transcription factors in COVID-19 Interleukin-37 gene polymorphism and susceptibility to coronavirus disease 19 among Iraqi patients Is there any relationship between serum zinc levels and angiotensin-converting enzyme 2 gene expression in patients with coronavirus disease 2019? Genetic analysis of IL4 (rs2070874), IL17A (rs2275913), and IL33 (rs7044343) polymorphisms in Iraqi multiple sclerosis patients by using T-plex real-time PCR method
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1