固体分散技术提高卢明三烯生物制药性能的最新进展:综述

IF 0.7 Q4 PHARMACOLOGY & PHARMACY Egyptian Pharmaceutical Journal Pub Date : 2023-01-01 DOI:10.4103/epj.epj_129_22
Priyanka Jurel, Anuj Garg
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引用次数: 0

摘要

背景鲁美ntrine是一种广泛应用的抗疟药物,与蒿甲醚联合使用。它的水溶性很差,属于生物制药分类II类。在过去的十年里,人们探索了各种提高其溶出率和口服生物利用度的策略。文献综述显示,基于固体分散体(SD)的各种方法已被研究用于此目的,并对其在体内的益处进行了评估。因此,本文的主要重点是回顾过去十年来对不同聚合物的流明三烯SD的研究。这篇综述还讨论了基于分子排列和所用聚合物或载体的SD的分类,以及它们的优缺点。这篇综述描述了制备流明三烯SD的不同技术及其对溶解度、溶出率和口服BA的影响。基于SD的方法显示出增加流明三ne口服BA的潜力。
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Recent advances in solid dispersion technique for enhancing biopharmaceutical properties of lumefantrine: an overview
Background Lumefantrine is a widely used antimalarial agent in combination with artemether. It is poorly water soluble and belongs to the biopharmaceutical classification class II. In the last decade, various strategies have been explored for increasing its dissolution rate and oral bioavailability (BA). A literature review revealed that various approaches based on solid dispersion (SD) have been investigated for this purpose and also evaluated for their benefits in vivo. Therefore, the major focus of the present article is to review the research carried out on the SD of lumefantrine with different polymers in the last decade. This review also discusses the classifications of SD based on their molecular arrangements and the polymers or carriers used, along with their advantages and disadvantages. This review described different techniques to prepare a SD of lumefantrine and their effects on solubility, dissolution rates, and oral BA. The SD-based approaches showed promising potential for increasing the oral BA of lumefantrine.
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来源期刊
Egyptian Pharmaceutical Journal
Egyptian Pharmaceutical Journal PHARMACOLOGY & PHARMACY-
CiteScore
1.10
自引率
0.00%
发文量
37
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