护理点诊断:用于增强生物传感器选择性和转导的分子印迹聚合物和纳米材料

IF 1.2 Q3 MULTIDISCIPLINARY SCIENCES The EuroBiotech Journal Pub Date : 2020-10-01 DOI:10.2478/ebtj-2020-0023
Daniel J. Denmark, S. Mohapatra, S. Mohapatra
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引用次数: 5

摘要

摘要由个人财富、出生环境、教育水平等因素造成的严重医疗保健差距在国际上普遍存在。因此,生物医学科学的进步使全球人口中的少数人受益匪浅。护理点检测(POCT)可以使医疗诊断变得负担得起、方便快捷,从而有助于社会平衡。不幸的是,传统的POCT在取得重大进展方面似乎停滞不前。这归因于与传统生物认知相关的高成本和不稳定性:主要是抗体,但也使用了核酸、细胞、酶和适体。相反,最先进的生物传感器研究人员越来越多地利用分子印迹聚合物(MIPs),因为它们具有高选择性、优异的稳定性以及对各种物理和化学操作的适应性。除了消除了传统的生物感受器外,纳米材料的加入进一步提高了生物传感器的灵敏度。本文系统地综述了利用MIPs进行选择性的现代纳米生物传感器和用于改进转导的纳米材料。首先,简要介绍了选择性演示的制造和广泛的挑战。之后,讨论转向对过去五年中发表的相关案例研究的分析。通过两个视角进行分析:采用特定纳米材料的基于MIP的生物传感器和采用特定转导策略的生物传感器。最后,通过推进该领域的建议,提出了结论,并展望了未来。希望这项工作将加速该领域的成功努力,引导新的研究人员,并为人人享有公平的医疗保健做出贡献。
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Point-of-Care Diagnostics: Molecularly Imprinted Polymers and Nanomaterials for Enhanced Biosensor Selectivity and Transduction
Abstract Significant healthcare disparities resulting from personal wealth, circumstances of birth, education level, and more are internationally prevalent. As such, advances in biomedical science overwhelmingly benefit a minority of the global population. Point-of-Care Testing (POCT) can contribute to societal equilibrium by making medical diagnostics affordable, convenient, and fast. Unfortunately, conventional POCT appears stagnant in terms of achieving significant advances. This is attributed to the high cost and instability associated with conventional biorecognition: primarily antibodies, but nucleic acids, cells, enzymes, and aptamers have also been used. Instead, state-of-the-art biosensor researchers are increasingly leveraging molecularly imprinted polymers (MIPs) for their high selectivity, excellent stability, and amenability to a variety of physical and chemical manipulations. Besides the elimination of conventional bioreceptors, the incorporation of nanomaterials has further improved the sensitivity of biosensors. Herein, modern nanobiosensors employing MIPs for selectivity and nanomaterials for improved transduction are systematically reviewed. First, a brief synopsis of fabrication and wide-spread challenges with selectivity demonstration are presented. Afterward, the discussion turns to an analysis of relevant case studies published in the last five years. The analysis is given through two lenses: MIP-based biosensors employing specific nanomaterials and those adopting particular transduction strategies. Finally, conclusions are presented along with a look to the future through recommendations for advancing the field. It is hoped that this work will accelerate successful efforts in the field, orient new researchers, and contribute to equitable health care for all.
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来源期刊
The EuroBiotech Journal
The EuroBiotech Journal Agricultural and Biological Sciences-Food Science
CiteScore
3.60
自引率
0.00%
发文量
17
审稿时长
10 weeks
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