将抗癌药物重新定位为新的新冠肺炎抗病毒药物:靶向病毒蛋白和癌症之间的结构和功能相似性

IF 4.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Expert Reviews in Molecular Medicine Pub Date : 2022-04-22 DOI:10.1017/erm.2022.11
Zheng Yao Low, Ashley Jia Wen Yip, Sunil Kumar Lal
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引用次数: 0

摘要

摘要由SARS-CoV-2引起的当前新冠肺炎大流行迫切需要新的、有前景的抗病毒疗法。病毒RNA依赖性RNA聚合酶(RdRp)酶在包括严重急性呼吸系统综合征冠状病毒2型在内的所有RNA病毒的病毒复制中发挥着至关重要的作用,从而使其成为新型抗病毒靶向的主要和有前途的候选物。有趣的是,人类端粒酶逆转录酶(hTERT)是许多癌症中常见的端粒酶催化亚基,其结构和功能也与病毒RdRp相似。因此,有必要评估和考虑靶向hTERT的抗病毒RdRp活性的抗癌药物,反之亦然。例如,hTERT抑制剂Floxuridine和丙型肝炎病毒RdRp抑制剂VX-222目前被公认为同时对抗SARS-CoV-2和抗hTERT的潜在抗病毒药物。虽然对用作病毒RdRp的hTERT抑制剂和用作hTERT抑制物的抗RdRp抑制剂的研究有限,但在这篇综述中,我们的目的是揭示这两种酶之间密切的结构和功能关系。我们用具体的例子来强调这一观点,说明与癌症研究领域相比,潜在的抗癌抑制剂如何有效地用作对抗SARS-CoV-2病毒的抑制剂,这是一种相对较新的病原体。
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Repositioning anticancer drugs as novel COVID-19 antivirals: targeting structural and functional similarities between viral proteins and cancer.
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来源期刊
Expert Reviews in Molecular Medicine
Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
7.40
自引率
1.60%
发文量
45
期刊介绍: Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.
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