Efe Kurtdede, M. E. Alçığır, A. Alperen, Berk Baran, Oğuz Kaan Karaca, Erman Gülendağ
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Evaluation of the Combined Effects of Turkish Mad Honey and 5-Fluorouracil in Colon Cancer Model in Rats
In N-methyl-N-nitrosourea (MNU)-induced colon cancer modeling in rats, it was aimed to evaluate the regressive effect of grayanotoxin-rich Turkish mad honey and 5-fluorouracil (5-FU), separately and together. Study groups were control group (CG), cancer control group (CCG), 5-Flourouracil group (FUG), Turkish mad honey group (HG), Turkish mad honey and 5-FU combined group (FU-HG). WBC, lymphocyte, eosinophil, basophil, serum LDH, TOS, and total protein values determined in the rats in the CCG were significantly lower than the values determined in the rats in CG, and serum Bcl-2 and survivin levels were significantly higher. The presence of anaplastic epithelial cells, vascularization, precancerous changes, and inflammatory infiltration detected in the colon and small intestine of the rats in FU-HG, FUG, HG were less intense (p
期刊介绍：
Ankara Üniversitesi Veteriner Fakültesi Dergisi is one of the journals’ of Ankara University, which is the first well-established university in the Republic of Turkey. Research articles, short communications, case reports, letter to editor and invited review articles are published on all aspects of veterinary medicine and animal science. The journal is published on a quarterly since 1954 and indexing in Science Citation Index-Expanded (SCI-Exp) since April 2007.
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