2018-2020年伊朗东南部三级保健中心儿童身材矮小的原因

IF 0.3 Q4 PEDIATRICS Journal of Pediatrics Review Pub Date : 2022-03-06 DOI:10.32598/jpr.10.1.980.1
V. Sheikhi, Shamim Bonyadi, Zahra Heidari
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引用次数: 0

摘要

目的:身材矮小是内分泌科医生经常遇到的问题。本研究的目的是评估到内分泌科就诊的儿童矮小的常见原因的频率。材料和方法:本前瞻性描述性研究于2018年8月至2020年9月进行。纳入的标准是:年龄小于18岁,身高低于平均值2个标准差(<第3个百分位数),生长衰竭(< 4厘米/年),中等父母身高较小,随访充分。他们通过人体测量进行评估;生化小组;荷尔蒙测试;放射学研究;还有荷尔蒙刺激测试结果:509例患者中,男性238例(46.8%),女性271例(53.2%)。参与者的年龄在2-18岁之间。平均实足年龄11.83±3.44岁。大多数研究参与者都在10岁以上(68%)。正常生长变异271例(53.34%)为最常见的病因。这些原因包括三个亚组:家族性身材矮小:133例(26.14%);体质性发育迟缓和青春期:112例(22%);特发性身材矮小26例(5.12%)。238例(46.66%)为病理类型所致。该组中身材矮小的主要原因是生长激素缺乏症,70例(13.76%)患者中有生长激素缺乏症。结论:身材矮小的正常变异是导致身材矮小的最常见原因,其次是内分泌原因,其次是非内分泌原因。
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Causes of short stature in children referred to a tertiary care center in Southeast of Iran: 2018-2020
Objective: Short stature is a common problem encountered by endocrinologists. The objective of this study was to evaluate the frequency of common causes of short stature in children referred to the endocrinology clinic. Material and Methods: This prospective and descriptive study was carried out between August 2018 and September 2020. Included criteria were: age below 18 years, height more than 2 SD below the mean (< 3rd percentile), growth failure (< 4 cm/year), small for mid-parental height, and adequate follow-up. They were evaluated by anthropometric measurements; biochemical panel; hormonal tests; radiological studies; and hormonal provocative tests. Results: A total of 509 cases, 238 males (46.8%), and 271 females (53.2%) had short stature. The age of participants varied between 2-18 years. The mean chronological age was 11.83±3.44 years. Most study participants were over 10 years old (68%). Normal variants of growth with 271 (53.34%) children, were the most prevalent causes. These causes included in three subgroups: Familial short stature: 133 (26.14%); Constitutional delay of growth and puberty: 112 (22%); and Idiopathic short stature: 26 (5.12%). Totally 238 cases (46.66%) were due to pathologic types of Short Stature. The leading cause of short stature in this group was Growth Hormone deficiency that is seen in 70 (13.76%) patients. Conclusion: The normal variants of short stature as a group were the most common cause of short stature, followed by endocrinological causes of short stature and non-endocrinological causes.
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