耳瘢痕疙瘩的顺序和联合有效治疗:一种采用烧蚀CO2和染料激光治疗的新治疗方案-一项先进的单中心临床研究

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Cosmetics Pub Date : 2023-09-08 DOI:10.3390/cosmetics10050126
Simone Amato, S. Nisticò, Giovanni Pellacani, Stefania Guida, Anthony Rossi, Caterina Longo, E. Berardesca, G. Cannarozzo
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引用次数: 0

摘要

耳瘢痕疙瘩在美学和功能上提出了重大挑战,而传统的治疗方法往往无法解决这些问题。我们的研究提出了一种创新的CO2消融和染料激光联合治疗瘢痕疙瘩的方法。在对瘢痕疙瘩成分进行初步多光谱分析后,将该治疗方案应用于15例耳廓瘢痕疙瘩患者。基于该分析,为每位患者量身定制激光序列。使用温哥华疤痕量表和患者和观察者疤痕评估量表在基线和治疗后3周间隔进行评估。结果显示,在最后的随访中,这些评分显著降低(p<0.05),表明瘢痕疙瘩的颜色、质地和柔韧性有所改善,不良事件最少。此外,未观察到瘢痕疙瘩复发。我们的研究结果表明,这种多光谱分析和量身定制的激光治疗的新方法可能为耳廓瘢痕疙瘩提供一种安全有效的解决方案,有望加强瘢痕疙瘩的治疗和预防复发。然而,还需要进一步的研究,包括随机对照试验,来确认和优化这一治疗方案。
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Sequential and Combined Efficacious Management of Auricular Keloid: A Novel Treatment Protocol Employing Ablative CO2 and Dye Laser Therapy—An Advanced Single-Center Clinical Investigation
Auricular keloids pose significant aesthetic and functional challenges, and traditional treatments often fall short in addressing these issues. Our study presents an innovative combined approach of ablative CO2 and dye laser therapy for improved keloid management. This treatment protocol was applied to 15 patients with auricular keloids after an initial multispectral analysis to assess keloid composition. The laser sequence was tailored per patient based on this analysis. Evaluations using the Vancouver Scar Scale and Patient and Observer Scar Assessment Scale were carried out at baseline and at 3-week intervals post-treatment. The results showed a significant reduction in these scores at the final follow-up (p < 0.05), suggesting improvements in keloid color, texture, and pliability, with minimal adverse events. Additionally, no recurrence of keloids was observed. Our findings indicate that this novel methodology of multispectral analysis followed by tailored laser therapy may offer a safe and effective solution for auricular keloids, promising enhanced keloid treatment and prevention of recurrence. However, further investigations, including randomized controlled trials, are needed to confirm and optimize this treatment protocol.
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来源期刊
Cosmetics
Cosmetics Medicine-Surgery
CiteScore
5.20
自引率
12.10%
发文量
108
审稿时长
8 weeks
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