橙皮苷作为神经保护剂的治疗潜力和临床证据。

Q3 Psychology Central nervous system agents in medicinal chemistry Pub Date : 2022-04-04 DOI:10.2174/1871524922666220404164405

S. Joshi, A. Dhingra, B. Chopra, Kumar Guarve, Deepak K Bhateja

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引用次数: 3

摘要

背景神经保护是在各种神经退行性疾病中保留神经功能，如阿尔茨海默氏症、亨廷顿舞蹈症、帕金森氏症和多发性硬化症。橙皮苷是柑橘类水果（如甜橙和柠檬）中的一种黄烷酮糖苷，具有多种生物学作用，包括神经保护作用。目的探讨橙皮苷治疗神经退行性疾病的神经药理学机制和治疗潜力。METHODIt强调比较和临床试验研究，从PubMed、Science Direct、Clinicaltrails.gov和许多知名基金会的数据中审查了一些靶点。结果越来越多的临床证据表明橙皮苷对神经退行性疾病有抑制作用。橙皮苷的神经保护潜力通过内源性抗氧化防御功能、改善神经生长因子、抗炎活性和凋亡途径来表征。结论本研究强调了橙皮苷的有益神经药理学潜力，包括抗惊厥、抗抑郁、抗氧化、抗炎、记忆和增强运动的活性。

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Therapeutic Potential and Clinical Evidence of Hesperidin as Neuroprotective Agent.

BACKGROUND Neuroprotection is preserving neural function in various neurodegenerative diseases like Alzheimer's, Huntington's, Parkinson's, and multiple sclerosis. Hesperidin, a flavanone glycoside in citrus fruits such as sweet oranges and lemons, possesses many biological effects, including neuroprotection. OBJECTIVE To explore the neuropharmacological mechanisms and therapeutic potential of hesperidin in the management of neurodegenerative disorders. METHOD It emphasizes comparative and clinical trial studies with a number of targets reviewed from the data available on PubMed, Science Direct, Clinicaltrails.gov, and from many reputed foundations. RESULT Escalating clinical evidence has established the inhibitory effect of hesperidin in the management of neurodegenerative disorders. Neuroprotective potential of hesperidin is characterized through endogenous antioxidant defence functions, improvement of neural growth factors, anti-neuroinflammatory activity, and apoptotic pathways. CONCLUSION The present study highlights the beneﬁcial neuropharmacological potential of hesperidin including anticonvulsant, antidepressant, antioxidant, anti-inﬂammatory, memory, and locomotor enhancing activities.

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来源期刊

Central nervous system agents in medicinal chemistry Psychology-Neuropsychology and Physiological Psychology

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.