己酮茶碱对三甲基锡诱导的海马损伤和记忆障碍的保护作用

Q4 Pharmacology, Toxicology and Pharmaceutics Iranian Journal of Toxicology Pub Date : 2021-04-01 DOI:10.32598/IJT.15.2.738.1

M. Sakhaie, Atefeh Mohammad-Hosseini, M. Sadegh, B. Khansarinejad, S. Babaei

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引用次数: 0

摘要

方法：雄性Wistar大鼠60只，分为5组，每组12只。第1组接受生理盐水，而第2组接受单剂量TMT（8mg/kg）。其他四组接受8 mg/kg TMT加60、100或120 mg/kg PTX，每天两次，连续六天。采用放射臂迷宫任务研究大鼠的工作记忆和参考记忆。实验结束时，将大鼠的大脑取出并进行处理，以进行海马体的组织学研究。

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Pentoxifylline Protects Against Hippocampal Damage and Memory Impairment Induced by Trimethyltin

Methods: Sixty male Wistar rats were divided into five groups of 12 each. Group 1 received normal saline while Group 2 received a single dose of TMT (8 mg/kg). The other four groups received TMT at 8 mg/kg plus 60, 100 or 120 mg/kg PTX twice daily for six consecutive days. The rats’ working and reference memory were investigated, using radial arm maze tasks. At the end of the experiments, the rats’ brains were removed and processed for histological study of the hippocampus.

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