胃管内磷化铝中毒并爆炸为罕见现象1例

Mohd. Kaleem Khan, Faiz Ahmad, A. Mahmood, Jamal Azmat
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引用次数: 1

摘要

根据2015年印度国家犯罪记录局(NCRB)的数据,中毒自杀是第二大自杀死亡原因(27.9%)。磷化铝(ALP)是用于自杀的主要农业毒药,因为它的可用性没有得到适当的管制。磷化铝(ALP)是一种剧毒的固体熏蒸农药、灭鼠剂和杀虫剂。在印度、巴基斯坦、斯里兰卡和伊朗等发展中国家,它通常被用作室外和室内杀虫剂,因为它便宜、有效、没有有毒残留物,而且不会改变种子的生存能力。磷化铝(ALP)是一种剧毒熏蒸剂,在农业基础工业中普遍用作室内农药,用于粮食储存。ALP在摄入时与胃水发生反应,释放出高度易燃、剧毒的磷化氢气体。在过去的几十年里,ALP已经成为自杀中毒的首选药物,在一些国家,ALP很容易获得。高死亡率是由于严重的线粒体功能障碍导致细胞呼吸中断,导致组织缺氧和器官功能障碍。尽管进行了长期的研究,但没有开发出特定的解毒剂,治疗方法仍然是支持性的。磷化氢(PH3)自燃是一种罕见但非常特殊的现象,报道了在磷化铝中毒的情况下。在这里,我们分享我们在一起磷化氢(PH3)中毒案件中的经验,该案件在治疗过程中出现自燃和爆炸,引起了印度当地和全国媒体的关注。
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Aluminum Phosphide Poisoning and Blast in Gastric Tube a Rare Phenomenon- A Case Report
Suicide by poisoning is the second most common cause of death by suicide (27.9%) as per The National Crime Records Bureau (NCRB) India in 2015.Aluminum phosphide (ALP) is the leading agricultural poison used to commit suicide as where its availability is not properly regulated. Aluminum phosphide (ALP) is a highly toxic solid fumigant pesticide, rodenticide and insecticide. It is commonly used as outdoor and indoor pesticide in developing countries like India, Pakistan, Srilanka and Iran because it is a cheap, effective, free from toxic residue and do not alter the viability of seeds. Aluminium Phosphide (ALP) is a highly toxic fumigant which is used commonly as an indoor pesticide in agriculture based industry for storage of grains. ALP on ingestion reacts with a gastric water and release phosphine gas, which is highly flammable, and very toxic in nature. Over the last few decades ALP has emerged as an agent of choice being used as suicidal poisoning in a country where it is readily available. The high mortality rate is due to severe mitochondrial dysfunction leading to disruption of cellular respiration, causing tissue hypoxia and organ dysfunction. Despite long research no specific antidote could be developed and the treatment remained supportive. Spontaneous ignition of phosphine (PH3) is a rare but very peculiar phenomenon reported in the case of aluminium phosphide poisoning. Here we share our experience in a case of phosphine (PH3) poisoning, which presented with spontaneous ignition and blast during treatment which caught the attention of local and national media in India,
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期刊介绍: Asia Pacific Journal of Medical Toxicology (APJMT) aims to expand the knowledge of medical toxicology and tries to provide reliable information in this field for medical and healthcare professionals. APJMT mainly focuses on research related to medical toxicology issues in the Asia Pacific region and publishes articles on clinical and epidemiological aspects of toxicology, poisonings emergency care, addiction, drug interactions and adverse effects. The journal accepts and welcomes high quality papers in the form of original articles and rarely review articles, case reports and scientific letters relevant to medical practice in toxicology.
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