乳腺恶性肌上皮瘤;一个有趣的病例报告，病理，免疫组织化学结果和文献回顾

Q4 Medicine Human Pathology: Case Reports Pub Date : 2019-09-01 DOI:10.1016/j.hpcr.2019.200301

Ola A. Harb , Ahmed A. Obaya , Taha A. Baiomy , Loay M. Gertallah , Sherif Y. Yousif

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引用次数: 1

摘要

背景:乳腺恶性肌上皮瘤(MMB)是一种极其罕见的侵袭性恶性肿瘤。这种恶性肿瘤的生物学行为和患者的治疗结果尚未明确确定。假设mmb在形态学上难以与良性梭形细胞增生区分开。识别和进一步研究这些肿瘤的发生可能有助于发现新的分子靶点来治疗它。病例报告我们在此描述一例51岁 女性MMB病例的病理和免疫组织化学特征，以补充以往关于这种罕见侵袭性实体的生物学行为和管理策略的数据。我们已经用免疫组织化学证实了我们病例的诊断，因为恶性细胞除了高Ki-67标记指数外，还显示P63, SMA和S-100的弥漫表达。结论smmb是一种极为罕见的肿瘤，在乳腺恶性梭形细胞瘤的鉴别诊断中值得怀疑。

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Malignant myoepithelioma of the breast (MMB); An interesting case report with pathological, immunohistochemical findings and review of literature

Background

Malignant myoepithelioma (MMB) of the breast is an extremely rare and aggressive malignant tumor. The biological behavior of such malignancy and treatment outcomes of patients has not been clearly determined.

Hypothesis

MMB is morphologically difficult to be distinguished from benign spindle cell proliferations. Identification and further research on the genesis of these tumors could help to discover new molecular targets for its management.

Case report

We herein describe the pathological and immunohistochemical characteristics of a case of MMB in a 51 year-old woman to add to the previous data about biological behavior and management strategy of such a rare aggressive entity.

We have confirmed the diagnosis of our case using immunohistochemisrty because malignant cells revealed diffuse expression of P63, SMA and S-100 in addition to high Ki-67 labeling index.