早发性结直肠癌研究:差距与机遇

IF 2.7 Q3 ONCOLOGY Colorectal Cancer Pub Date : 2020-09-01 DOI:10.2217/crc-2020-0028

Laura Brockway-Lunardi, Stefanie A. Nelson, A. Pandiri, J. V. Tricoli, A. Umar, A. Wali, Phillip J. Daschner

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引用次数: 10

摘要

散发性早发性结直肠癌(EO-CRC)的发病率在美国和全球范围内迅速增加。出生队列分析强烈提示，早期生活暴露于已知或未知CRC危险因素的变化可能会导致EO-CRC疾病，但EO-CRC的病因学仍然知之甚少。为了应对散发性EO-CRC的惊人增长，国家癌症研究所和国家环境健康科学研究所召开了一次虚拟会议，由EO-CRC专家进行了演讲和重要讨论，审查了关于EO-CRC潜在风险因素、机制和筛查和治疗转化机会的新证据。

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Early-onset colorectal cancer research: gaps and opportunities

The incidence rates of sporadic early-onset colorectal cancer (EO-CRC) are increasing rapidly in the USA and globally. Birth cohort analyses strongly suggest that changes in early life exposures to known or unknown risk factors for CRC may be driving EO disease, but the etiology of EO-CRC remains poorly understood. To address the alarming rise in sporadic EO-CRC, the National Cancer Institute and National Institute of Environmental Health Sciences convened a virtual meeting that featured presentations and critical discussions from EO-CRC experts that examined emerging evidence on potential EO-CRC risk factors, mechanisms and translational opportunities in screening and treatment.

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来源期刊

Colorectal Cancer ONCOLOGY-

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期刊介绍： Colorectal cancer is a major cause of morbidity and mortality, particularly in the developed world. Risk factors for colorectal cancer are on the rise in many countries; populations are aging, and obesity and diabetes are increasing. National screening programs are helping to detect cancer while it is still curable; however, colorectal cancer remains the third leading cause of cancer deaths in the USA and options are still limited for those with more advanced disease. Consequently, colorectal cancer is a major research priority for government, pharmaceutical companies and non-profit organizations. Research into diagnosis and optimum treatment of the disease is progressing rapidly, with new advances reported every day. Colorectal Cancer presents reviews, analysis and commentary. on all aspects of colorectal cancer.