高敏感性心肌肌钙蛋白T2 (hscTnT2)对STEMI和NSTEMI伊拉克患者急性冠脉综合征的诊断价值及鉴别疗效评价

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL BioMedicine-Taiwan Pub Date : 2023-07-01 DOI:10.51248/.v43i3.2507
Ali Abdul Rasool Hussein, Ali Abdulateef Hasan Al-bayati, Abdulkareem H. Issa
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引用次数: 0

摘要

引言和目的:对急性冠状动脉综合征(ACS)的两种主要临床表现形式进行分类;心电图显示ST段抬高(STEMI)的急性心肌梗死(MI)和另一个非ST段抬高的非ST段升高(NSTEMI)。本研究使用新一代高灵敏度心肌肌钙蛋白T2(hscTnT2)对急性冠状动脉综合征患者进行设计,以评估其在区分STEMI和NSTEMI方面的诊断价值和疗效。材料和方法:120名被诊断为ACS的患者被纳入研究。显然,六十四(64)名健康受试者被视为对照。进行心电图和体重指数(BMI)检查。通过酶联免疫吸附试验(ELISA)测量血糖、脂质和谷草转氨酶(GOT)水平的血液分析,并估计人hscTnT2浓度。结果:与对照组相比,ACS患者(STEMI和NSTEMI)的hscTnT2、胆固醇、TG、HDL、GOT、FBS和VLDL水平显著升高。此外,STEMI患者血清(hscTnT2)水平225.95±120.66 ng/L显著高于NSEMI患者102.32±58.542 ng/L(P值<0.001)。hscTnT2对STEMI和NSTEMI的鉴别效果高,其截止值为90.3ng/L。结论:使用新一代高灵敏度肌钙蛋白T有助于将准确诊断急性心肌梗死的时间缩短到2小时以内。STEMI患者的hscTnT血清值高于NSTEMI患者,并且与ACS患者的心脏损伤程度呈正相关。hscTnT水平可以被认为是区分STEMI和NSTEMI患者的良好鉴别诊断生物标志物。
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Evaluation of the diagnostic value and differentiation efficacy of high sensitivity cardiac troponin T2 (hscTnT2) for STEMI and NSTEMI Iraqi patients with acute coronary syndrome
Introduction and Aim: Two major clinical forms of acute coronary syndrome (ACS) were categorized; acute myocardial infarction (MI) showing ST-segment elevation (STEMI) with ECG, the other non-ST-segment elevation (NSTEMI). This study was designed using a new generation of high sensitivity cardiac troponin T2 (hscTnT2) in patients with acute coronary syndrome to evaluate the diagnostic value and its efficacy in differentiation of STEMI from NSTEMI.   Materials and Methods: one hundred twenty (120) patients diagnosed to have ACS were included in the study. Apparently, sixty-four (64) healthy subjects were considered as control.  ECG and body mass index (BMI) were performed. Blood analysis of levels of glucose, lipid profile and glutamic-oxaloacetic transaminase (GOT) were measured as well as estimated the human hscTnT2 concentrations by enzyme linked immunosorbent assay (ELISA).   Results:  ACS patients (STEMI & NSTEMI) showed significant high levels (hscTnT2), Cholesterol, TG, HDL, GOT, FBS and VLDL compared to control. Furthermore, (hscTnT2) serum level in STEMI 225.95 ±120.66 ng/L is significantly higher (P value <0.001) than NSEMI 102.32 ± 58.542 ng/L. the discrimination efficacy of hscTnT2 to differentiating STEMI from NSTEMI is high with cut off value 90.3 ng/L with high sensitivity.   Conclusion: The use of new generations of high sensitivity troponin T aided to reduce the time for accurate diagnosis of acute MI to less than 2 hours. The hscTnT serum value was higher in STEMI than NSTEMI patients and shown to be positively correlated with the degree of cardiac damage in ACS patients. The level of hscTnT can be considered as good discriminating diagnostic biomarkers to differentiate STEMI from NSTEMI patients.
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来源期刊
BioMedicine-Taiwan
BioMedicine-Taiwan MEDICINE, GENERAL & INTERNAL-
CiteScore
2.80
自引率
5.90%
发文量
21
审稿时长
24 weeks
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