多价噬菌体和含氧水&预防紧急腹部手术中手术部位感染的可能性

IF 0.6 Archiv EuroMedica Pub Date : 2023-08-23 DOI:10.35630/2023/13/4.812

DMITRY PARSHIN, Vyacheslav Mykhaylichenko, A. Kupriyanov, Ramazan Alibekov, R. Mardanov, Enver Kеrimov, G. Puchkina, O. Bezrukov, A. Abdullaev

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引用次数: 0

摘要

我们对多价噬菌体和氧合水预防SSI的有效性进行了单中心研究。研究对象为88例因急诊腹部病理行腹部外科手术的SSI高危患者(ACS NSQIP)， SSI发生率为0.30±3%。噬菌体局部和肠内给药，而OW仅肠内给药。研究结果表明，PVBP联合OW可使诱导的肠内病理组正常化，减少病原体污染，增强肠细胞的保护能力，早期阻止肠衰竭，使SSI的风险降低2倍以上。

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POLYVALENT BACTERIOPHAGES AND OXYGENATED WATER – POSSIBILITIES FOR PREVENTION OF SURGICAL SITE INFECTION DURING EMERGENCY ABDOMINAL SURGERY

We carried out a single-center study of the effectiveness of polyvalent bacteriophages and oxygenated water for the prevention of SSI. The object was 88 patients who had undergone abdominal surgery for emergency abdominal pathology with a high risk of SSI >30±3% (ACS NSQIP). Phages were administered topically and enterally, while OW only enterally. As a result of the study, it turned out that the combined use of PVBP and OW allows to normalize the induced enteral pathobiome, to reduce pathogen contamination, to enhance the protective capabilities of enterocytes, to stop intestinal failure in the early stages and to reduce the risk of SSI by more than 2 times.

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来源期刊

Archiv EuroMedica MEDICINE, GENERAL & INTERNAL-

自引率

83.30%

发文量

140