干细胞疗法治疗膝骨关节炎

Alexandra Meekin, Cody A. Sasek
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引用次数: 0

摘要

膝关节骨性关节炎(KOA)是一种肌肉骨骼疾病,会导致关节软骨进行性退化,导致疼痛和功能丧失。保守治疗侧重于镇痛药和非甾体抗炎药的症状缓解。间充质干细胞具有免疫抑制和抗炎特性,旨在改变疾病过程。患者在MSC治疗后发现功能和疼痛有所改善。MSC治疗可以稳定软骨,但没有明确的再生。MSC治疗可能是那些想要停止或延迟疾病过程的人的一种治疗选择。本文综述了MSC治疗KOA患者的最新文献。
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Stem-Cell Therapy for the Treatment of Knee Osteoarthritis
Knee osteoarthritis (KOA) is a musculoskeletal disorder that causes progressive degeneration of the articular cartilage leading to pain and loss of function. Conservative treatment focuses on symptomatic relief with analgesics and nonsteroidal anti-inflammatory drugs. Mesenchymal stem cells (MSCs) have immunosuppressive and anti-inflammatory properties that aim to modify the disease process. Patients find improvement in function and pain after MSC therapy. MSC treatment stabilizes the cartilage, but there is no definitive regeneration. MSC therapy could be a treatment option for those wanting to stop or delay the disease process. This article reviews the current literature on the use of MSC therapy for patients with KOA.
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