{"title":"干细胞疗法治疗膝骨关节炎","authors":"Alexandra Meekin, Cody A. Sasek","doi":"10.2106/JBJS.JOPA.21.00027","DOIUrl":null,"url":null,"abstract":"Knee osteoarthritis (KOA) is a musculoskeletal disorder that causes progressive degeneration of the articular cartilage leading to pain and loss of function. Conservative treatment focuses on symptomatic relief with analgesics and nonsteroidal anti-inflammatory drugs. Mesenchymal stem cells (MSCs) have immunosuppressive and anti-inflammatory properties that aim to modify the disease process. Patients find improvement in function and pain after MSC therapy. MSC treatment stabilizes the cartilage, but there is no definitive regeneration. MSC therapy could be a treatment option for those wanting to stop or delay the disease process. This article reviews the current literature on the use of MSC therapy for patients with KOA.","PeriodicalId":93583,"journal":{"name":"Journal of orthopedics for physician assistants","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Stem-Cell Therapy for the Treatment of Knee Osteoarthritis\",\"authors\":\"Alexandra Meekin, Cody A. Sasek\",\"doi\":\"10.2106/JBJS.JOPA.21.00027\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Knee osteoarthritis (KOA) is a musculoskeletal disorder that causes progressive degeneration of the articular cartilage leading to pain and loss of function. Conservative treatment focuses on symptomatic relief with analgesics and nonsteroidal anti-inflammatory drugs. Mesenchymal stem cells (MSCs) have immunosuppressive and anti-inflammatory properties that aim to modify the disease process. Patients find improvement in function and pain after MSC therapy. MSC treatment stabilizes the cartilage, but there is no definitive regeneration. MSC therapy could be a treatment option for those wanting to stop or delay the disease process. This article reviews the current literature on the use of MSC therapy for patients with KOA.\",\"PeriodicalId\":93583,\"journal\":{\"name\":\"Journal of orthopedics for physician assistants\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of orthopedics for physician assistants\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2106/JBJS.JOPA.21.00027\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of orthopedics for physician assistants","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2106/JBJS.JOPA.21.00027","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Stem-Cell Therapy for the Treatment of Knee Osteoarthritis
Knee osteoarthritis (KOA) is a musculoskeletal disorder that causes progressive degeneration of the articular cartilage leading to pain and loss of function. Conservative treatment focuses on symptomatic relief with analgesics and nonsteroidal anti-inflammatory drugs. Mesenchymal stem cells (MSCs) have immunosuppressive and anti-inflammatory properties that aim to modify the disease process. Patients find improvement in function and pain after MSC therapy. MSC treatment stabilizes the cartilage, but there is no definitive regeneration. MSC therapy could be a treatment option for those wanting to stop or delay the disease process. This article reviews the current literature on the use of MSC therapy for patients with KOA.