老鼠和人的最佳计划

R. Robbins, Phoenix Pulmonary, P. Harber, Allen Thomas
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引用次数: 0

摘要

没有可用的摘要。文章在150字后被截断。在撰写拨款提案时,我们中的许多人都会进行幂分析,以确保我们有足够的数字或“n”来检测两个群体之间的统计显著差异。我们通过考虑可能的组间差异来估计每组所需的人数,然后根据不给予知情同意、拒绝、死亡、无法随访等的人数增加额外的受试者。通常,非受试者的人数是根据以前的经验估计的,但有时会先进行一项小型研究,称为可行性研究,以测试招聘的假设。对于临床试验和流行病学研究,试点或可行性研究也有助于确保参与者能够代表相关人群(1)。(例如,只有病情最严重的人才会参加药物试验,或者最脆弱的工作人员会拒绝参加研究…
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The Best Laid Plans of Mice and Men
No abstract available. Article truncated after 150 words. When writing a grant proposal, many of us do a power analysis to ensure that we will have a sufficient number or “n” to detect a statistically significant difference between two populations. We estimate the number needed in each group by considering the likely intergroup difference and then add additional subjects depending on the number who will not give informed consent, refuse, die, are lost to follow up, etc. Often the number of nonparticipants is estimated based on previous experience, but sometimes a small study is done first called a feasibility study which tests the assumptions about recruitment. For both clinical trials and epidemiologic studies, a pilot or feasibility study also helps assure that participants will be representative of the relevant population (1). (For examples, will only the most seriously ill participate in a drug trial, or will the most vulnerable workers decline participation in a study. Will some drugs …
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