鼠李糖乳杆菌(ATCC 7469)软膏对Wistar大鼠二度烧伤创面的影响

A. Barzegari, Masood Hashemzaei, A. Alihemmati, S. Soltani, B. Naseri
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引用次数: 9

摘要

引言:烧伤是对受伤者造成巨大身心伤害的创伤之一。科学家们仍在寻找新的治疗方法和烧伤管理方法,这些方法和方法没有以前的缺陷。最近,益生菌在治疗皮肤病和问题方面的潜力已经得到了研究。考虑到益生菌的作用是菌株依赖性的,本研究的目的是评估鼠李糖乳杆菌(ATCC 7469)对烧伤愈合过程的影响。材料和方法:大鼠背部二度烧伤诱导后,随机分为实验组、载体对照组和阴性对照组。实验组接受细菌软膏治疗1、3、7和14天。与实验组一样,车辆对照组接受了持续时间的Eucerin。阴性对照组在同一天内未接受任何治疗。通过计算愈合百分比从宏观上评估伤口愈合,并通过不同日期伤口区域组织样本的苏木精和曙红染色从微观上评估伤口的愈合。结果:与对照组相比,实验组的伤口愈合率显著提高,直到实验的第7天。此外,显微镜结果表明,这种细菌可能具有一些抗炎作用。此外,细菌增加了伤口区域成纤维细胞迁移和再上皮化的速率。结论:总的来说,鼠李糖乳杆菌(ATCC 7469)在烧伤创面局部应用可能对烧伤创面的愈合过程有一定的积极作用。
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Effects of Lactobacillus rhamnosus (ATCC 7469) ointment on second-degree burn wound in Wistar rat
Introduction: Burn is among the traumas that impose great physical and psychological damages to the injured people. Scientists still are looking for new treatments and methods for burn management that lack the defects of previous ones. Recently, the potential of probiotic bacteria for the treatment of skin disease and problems has been investigated. Considering that the effects of probiotics are strain-dependent, the aim of current study was to evaluate the effects of Lactobacillus rhamnosus (ATCC 7469) on the process of burn wound healing. Materials and methods: After induction of second-degree burn wounds on the back of rats, they were randomly divided into experimental, vehicle control, and negative control groups. The experimental groups received a bacterial ointment for 1, 3, 7, and 14 days. The vehicle control groups received Eucerin for durations like the experimental groups. The negative control groups received no treatment in the same days. The evaluation of wound healing was conducted macroscopically by computing of the healing percent and microscopically by Hematoxylin and Eosin staining of the tissue samples of the wound area on different days. Results: The wound healing percent in the experimental group, compared with control groups, significantly increased, until the day 7 of the experiments. Moreover, the microscopic results indicate that the bacteria may have some anti-inflammatory effects. Also, the bacteria increased the rate of fibroblastic migration and re-epithelialization in the wound area. Conclusion: Overall, L. rhamnosus (ATCC 7469) when used topically on the burn wounds may have some positive effects on the process of burn wound healing.
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