黄疸新生儿经皮胆红素测定与血清总胆红素测定的比较研究

Bahjat Abdulridha Alsaeedi, R. Mohammed, Waad Edan Louis Al-Rubaye
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引用次数: 0

摘要

背景:抽血测定血清总胆红素是一项痛苦而耗时的工作。利用前额或胸骨上部皮肤表面的多波长光谱反射进行经皮胆红素测定是一种快速无痛的技术。目的:比较经皮(胸骨上部和前额)和血清胆红素测定对新生儿黄疸的有效性。受试者和方法:这是一项横断面前瞻性研究。该研究招募了175名黄疸新生儿,排除了接受光疗的新生儿。该研究于2018年8月1日至10月30日在伊拉克巴格达的儿童中心教学医院进行。用JM103美能达空气屏蔽胆红素计经皮测量前额和胸骨上部胆红素。采用APEL BR 501胆红素仪测定血清总胆红素。使用SPSS 20计算机软件输入和分析数据。计算平均值、频率、截止值、敏感性和特异性。结果:平均年龄(6.3±4.3天),孕龄(36.9±2.1周),出生体重(2.7±0.6公斤)。平均血清总胆红素、经皮胸部和前额胆红素水平分别为12.6±4.2 mg/dl、11.8±3.8 mg/dl和11.2±3.9 mg/dl。平均血清总胆红素显著高于经皮胸部和前额胆红素。经皮胸部和前额胆红素水平的截止值分别为[(9mg/dl),敏感性(95.4%)和特异性(86.4%)]和[(8.2mg/dl),敏感度(94.7%)和特异度(86.4%]。结论:胸部和前额经皮胆红素测量在预测高胆红素血症方面具有可接受的有效性,但前额的准确性较差。
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A Comparative Study between Transcutaneous Bilirubinometry and Total Serum Bilirubin Measurement in Jaundiced Newborns
Background: Drawing blood to measure total serum bilirubin is painful & time consuming. Transcutaneous bilirubinometer working by multiwavelength spectral reflectance from the skin surface on forehead or upper sternum is a quick & painless technique.  Objectives: to compare the effectiveness of transcutaneous (over the upper sternum and forehead) and serum bilirubin measurement of neonate with jaundice. Subjects and Methods: This is a cross sectional prospective study. It enrolled 175 jaundiced neonates & excluded those exposed to phototherapy. It was conducted at Child Central Teaching Hospital in Baghdad, Iraq from the 1st of August to the 30th of October 2018. Transcutaneous bilirubin measurement on forehead and upper sternum was done by JM 103 Minolta Air shields bilirubinometer. Total serum bilirubin was measured by APEL BR 501 BILIRUBIN METER. Data entered & analyzed using SPSS 20 computer software. Means, frequencies, cutoff values, sensitivity & specificity were calculated.  Results: The mean age, gestational age & birth weight were (6.3±4.3 days), (36.9±2.1 weeks) and (2.7±0.6 Kg) respectively. Mean total serum bilirubin, transcutaneous chest & forehead bilirubin levels were 12.6±4.2 mg/dl, 11.8±3.8 mg/dl & 11.2±3.9 mg/dl respectively. Mean total serum bilirubin was significantly higher than transcutaneous chest and forehead bilirubin. Cutoff values of transcutaneous chest & forehead bilirubin levels were [(9 mg/dl) with sensitivity (95.4%) & specificity (86.4%)] and [(8.2 mg/dl) with sensitivity (94.7%) & specificity (86.4%)] respectively. Conclusions: Transcutaneous bilirubin measurements on chest and forehead have an acceptable validity in predicting hyperbilirubinemia with less accuracy on forehead.
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CiteScore
0.10
自引率
0.00%
发文量
34
审稿时长
12 weeks
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