金属有机框架(MOFS)作为DNA和RNA递送的非病毒载体:综述

IF 4.1 3区 化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR Reviews in Inorganic Chemistry Pub Date : 2022-06-03 DOI:10.1515/revic-2022-0004
Gabriela Soriano-Giles, Edwin A. Giles-Mazón, Nazario Lopez, E. Reinheimer, V. Varela-Guerrero, María F. Ballesteros-Rivas
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引用次数: 4

摘要

摘要金属有机框架(MOFs)是一类晶体材料,由于其大的表面积和高的孔隙率,使其能够用于各种知识领域。这种应用的多样性是由于金属离子和组成它们的有机粘合剂,但强调MOFs作为各种大小和化学性质非常不同的分子的宿主的能力也很重要。讨论了将生物分子掺入MOFs的第一种现有方法:孔包封、表面结合、共价结合和原位包封。接下来,我们讨论了设计用于有效基因递送的MOFs的障碍,以及如何使用不同的策略来增强基因递送。
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Metal organic frameworks (MOFS) as non-viral carriers for DNA and RNA delivery: a review
Abstract Metal-Organic Frameworks (MOFs) are a class of crystalline materials that, thanks to their large surface area and high porosity, allow them to be used in various areas of knowledge. This diversity of applications is due to the metal ions and the organic binders that compose them, but it is also important to highlight the ability of MOFs to function as hosts for a great variety of molecules of very different sizes and chemical properties. The first existing approaches for incorporating biomolecules in MOFs are discussed: pore encapsulation, surface binding, covalent binding, and in-situ encapsulation. Next, we discuss the obstacles of designing MOFs for effective gene delivery and how to enhance the gene delivery using different strategies.
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来源期刊
Reviews in Inorganic Chemistry
Reviews in Inorganic Chemistry 化学-分析化学
CiteScore
7.30
自引率
4.90%
发文量
20
审稿时长
1 months
期刊介绍: Reviews in Inorganic Chemistry (REVIC) is a quarterly, peer-reviewed journal that focuses on developments in inorganic chemistry. Technical reviews offer detailed synthesis protocols, reviews of methodology and descriptions of apparatus. Topics are treated from a synthetic, theoretical, or analytical perspective. The editors and the publisher are committed to high quality standards and rapid handling of the review and publication process. The journal publishes all aspects of solid-state, molecular and surface chemistry. Topics may be treated from a synthetic, theoretical, or analytical perspective. The editors and the publisher are commited to high quality standards and rapid handling of the review and publication process. Topics: -Main group chemistry- Transition metal chemistry- Coordination chemistry- Organometallic chemistry- Catalysis- Bioinorganic chemistry- Supramolecular chemistry- Ionic liquids
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