Efek pemberian astaxanthin (Haematococcus pluvialis) terhadap ukuran diameter pada model ulkus traumatikusThe effect of astaxanthin (Haematococcus pluvialis) on diameter measurement in traumatic ulcer model

Introduction: The prevalence of traumatic ulcers in Indonesia is high (96,6%). Astaxanthin, derived from the green microalgae Haematococcus Pluvialis, is one of the alternative treatments for ulcer healing due to its potent antioxidant and anti-inflammatory effect. This study aimed to analyze astaxanthin’s effectiveness on the difference in the diameter of the ulcer on day 1 and day 3 in a traumatic ulcer model. Methods: Samples of 30 Wistar rats were randomly divided into 5 groups which were treated with traumatic ulcers and then treated for 3 days according to their respective groups: K-(control group given gel base); K+ (control group given hyaluronic acid); P1 (application of 0.1% astaxanthin); P2 (application of 0.5% astaxanthin); P3 (application of 1% astaxanthin). The data results were then carried out with one way ANOVA test, and the Post Hoc LSD test proceeded with p=0,05. Results: The statistical parametric test using One Way ANOVA showed a significant difference (p<0,05) in the diameter ulcer on day 1 and day 3. Post Hoc LSD test showed a significant difference (p<0,05) between K-(5,300 ± 2,832) compare to K+ (2,297 ± 1,045), P1(1,740 ± 1,168), P2(1,993 ± 0,738), and P3 (2,448 ± 1,320). Conclusions: There is an effect of giving astaxanthin gel in reducing the difference in the diameter of the ulcer on day 1 and day 3 on the healing process of traumatic ulcer.