X. Lei, G. Combs, R. Sunde, J. Caton, J. Arthington, M. Vatamaniuk
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This review traces the discoveries that led to the recognition of selenium (Se) as an essential nutrient and discusses Se-responsive diseases in animals and humans in the context of current understanding of the molecular mechanisms of their pathogeneses. The article includes a comprehensive analysis of dietary sources, nutritional utilization, metabolic functions, and dietary requirements of Se across various species. We also compare the function and regulation of selenogenomes and selenoproteomes among rodents, food animals, and humans. The review addresses the metabolic impacts of high dietary Se intakes in different species and recent revelations of Se-metabolites, means of increasing Se status, and the recycling of Se in food systems and ecosystems. Finally, research needs are identified for supporting basic science and practical applications of dietary Se in food, nutrition, and health across species. Expected final online publication date for the Annual Review of Nutrition, Volume 42 is August 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
期刊介绍：
Annual Review of Nutrition
Publication History:In publication since 1981
Scope:Covers significant developments in the field of nutrition
Topics Covered Include:
Energy metabolism;
Carbohydrates;
Lipids;
Proteins and amino acids;
Vitamins;
Minerals;
Nutrient transport and function;
Metabolic regulation;
Nutritional genomics;
Molecular and cell biology;
Clinical nutrition;
Comparative nutrition;
Nutritional anthropology;
Nutritional toxicology;
Nutritional microbiology;
Epidemiology;
Public health nutrition
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