新型噻唑吡啶类有效抗炎候选药物的研制

Q4 Biochemistry, Genetics and Molecular Biology Ukrainian Biochemical Journal Pub Date : 2020-04-17 DOI:10.15407/ubj92.02.132

T. Chaban, V. Matiychuk, V. Ogurtsov, I. Chaban, I. Nektegayev

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引用次数: 7

摘要

为了开发新的抗炎剂，合成了一系列噻唑并[4,5-b]吡啶，并在N3位进行了修饰。通过1h-NMr光谱和元素分析证实了所得化合物的结构。通过分子对接预先选择合成的物质，以在体外测试其抗炎活性。使用卡拉胶诱导的大鼠爪水肿法对化合物进行评估显示，一些化合物（1，2，8）具有强的抗炎作用，其超过布洛芬。

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Development of effective anti-inflammatory drug candidates among novel thiazolopyridines

In an effort to develop novel anti-inflammatory agents, a series of thiazolo[4,5-b]pyridines were synthesized and modified at the N3 position. The structures of the obtained compounds were confirmed by 1h NMr spectroscopy and elemental analysis. The synthesized substances were preselected via molecular docking to be tested for their anti-inflammatory activity in vitro. Evaluation of compounds using the carrageenaninduced rat paw edema method showed strong anti-inflammatory action of some compounds (1, 2, 8) which exceeded that of ibuprofen.

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来源期刊

Ukrainian Biochemical Journal Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

16 weeks

期刊介绍： The Ukrainian Biochemical Journal publishes original research papers, reviews and brief notes; papers on research methods and techniques; articles on the history of biochemistry, its development and prominent figures; discussion articles; book reviews; chronicles; etc. The journal scope includes not only biochemistry but also related sciences, such as cellular and molecular biology, bioorganic chemistry, biophysics, pharmacology, genetics, and medicine (medical biochemistry et al.) – insofar as the studies use biochemical methods and discuss biochemical findings.