反式白藜芦醇对B6C3F1/N雄性小鼠的免疫毒性研究

IF 2.4 4区 医学 Q3 TOXICOLOGY Journal of Immunotoxicology Pub Date : 2020-01-01 DOI:10.22427/ntp-data-002-02772-0033-0000-6
Madelyn C. Huang, K. White, S. Elmore, T. Guo, D. Germolec
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引用次数: 2

摘要

摘要白藜芦醇是一种天然存在的多酚,正被研究用于治疗和预防各种疾病,包括实验和临床。尽管由于其免疫调节特性,白藜芦醇的使用和兴趣有所增加,但缺乏评估与白藜芦醇使用相关的潜在毒性,特别是免疫毒性的研究。先前一项为期两周的研究发现,雄性B6C3F1/N小鼠的胸腺重量随着反式白藜芦醇暴露量的增加而降低。这项研究是通过评估免疫功能对这些发现的后续研究。雄性成年B6C3F1/N小鼠给予反式白藜芦醇(0,156,312,625,1250,2500 mg/kg/天)经口灌胃28天,并评估功能免疫测试和组织病理学。在研究期间,没有与治疗相关的体重影响。反式白藜芦醇治疗28天后,体液、细胞介导和先天免疫功能没有改变。器官重量也没有变化,免疫器官也没有微观变化。总体而言,在本研究的条件下,没有证据表明雄性小鼠口服反式白藜芦醇具有免疫毒性或免疫功能改善。重要的是,白藜芦醇的免疫调节作用可能需要先决条件水平的炎症活性,而在健康个体中可能无法观察到。
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Immunotoxicity studies of trans-resveratrol in male B6C3F1/N mice
Abstract Resveratrol is a naturally occurring polyphenol that is being investigated to treat and prevent various diseases, both experimentally and in the clinic. Despite increased use and interest in resveratrol due to its immunomodulatory properties, there is a lack of studies evaluating potential toxicities, particularly immunotoxicity, associated with resveratrol use. A previous 2-week study found decreasing thymus weight in male B6C3F1/N mice with increasing exposure to trans-resveratrol. This study is a follow-up on those findings by evaluating immune function. Male adult B6C3F1/N mice were given trans-resveratrol (0, 156, 312, 625, 1250, 2500 mg/kg/day) via oral gavage for 28 days and functional immune tests and histopathology were evaluated. There were no treatment-related effects on body weight during the study. Humoral, cell-mediated, and innate immune function were not altered after 28 days of trans-resveratrol treatment. There were also no changes in organ weight or microscopic alterations in immune organs. Overall, under the conditions of this study, there was no evidence of immunotoxicity or improvements in immune function associated with oral exposure to trans-resveratrol in male mice. Importantly, the immunomodulatory benefits of resveratrol may require a prerequisite level of inflammatory activity and may not be observable in healthy individuals.
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来源期刊
Journal of Immunotoxicology
Journal of Immunotoxicology 医学-毒理学
CiteScore
6.70
自引率
3.00%
发文量
26
审稿时长
1 months
期刊介绍: The Journal of Immunotoxicology is an open access, peer-reviewed journal that provides a needed singular forum for the international community of immunotoxicologists, immunologists, and toxicologists working in academia, government, consulting, and industry to both publish their original research and be made aware of the research findings of their colleagues in a timely manner. Research from many subdisciplines are presented in the journal, including the areas of molecular, developmental, pulmonary, regulatory, nutritional, mechanistic, wildlife, and environmental immunotoxicology, immunology, and toxicology. Original research articles as well as timely comprehensive reviews are published.
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