Nigora Rustamova, K. Bobakulov, Niu Litao, R. Nuerxiati, A. Wali, W. Setzer, A. Yili
{"title":"与驱虫Veronia相关的内生真菌Aspergillus terreus XJA8的次生代谢产物及其生物活性","authors":"Nigora Rustamova, K. Bobakulov, Niu Litao, R. Nuerxiati, A. Wali, W. Setzer, A. Yili","doi":"10.1080/22311866.2022.2154265","DOIUrl":null,"url":null,"abstract":"Abstract Two isocoumarins (6-methoxymellein and 6-hydroxymellein), one pyrrole compound (minaline), one lactone derivative (butyrolactone II), five phenolic acids (phenylacetic, veratric (3,4-dimethoxybenzoic), 4-hydroxyphenylacetic, 4-hydroxybenzoic and protocatechuic acid), and two phenolic acid methyl esters ((2-hydroxyphenyl) acetic acid methyl ester and methyl 4-hydroxyphenylacetate), along with 1,3-bis(4-hydroxyphenyl) propan-2-one were isolated from the fungal strain Aspergillus terreus XJA8. The fungal strain was isolated from the root of the medicinal plant Vernonia anthelmintica for first time. All isolated secondary metabolites were evaluated for their antimicrobial activity and melanin synthesis in murine B16 cells. GRAPHICAL ABSTRACT","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":null,"pages":null},"PeriodicalIF":0.9000,"publicationDate":"2022-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Secondary Metabolites and their Biological Activities from Endophytic Fungal Strain Aspergillus terreus XJA8 Associated with Vernonia anthelmintica\",\"authors\":\"Nigora Rustamova, K. Bobakulov, Niu Litao, R. Nuerxiati, A. Wali, W. Setzer, A. Yili\",\"doi\":\"10.1080/22311866.2022.2154265\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract Two isocoumarins (6-methoxymellein and 6-hydroxymellein), one pyrrole compound (minaline), one lactone derivative (butyrolactone II), five phenolic acids (phenylacetic, veratric (3,4-dimethoxybenzoic), 4-hydroxyphenylacetic, 4-hydroxybenzoic and protocatechuic acid), and two phenolic acid methyl esters ((2-hydroxyphenyl) acetic acid methyl ester and methyl 4-hydroxyphenylacetate), along with 1,3-bis(4-hydroxyphenyl) propan-2-one were isolated from the fungal strain Aspergillus terreus XJA8. The fungal strain was isolated from the root of the medicinal plant Vernonia anthelmintica for first time. All isolated secondary metabolites were evaluated for their antimicrobial activity and melanin synthesis in murine B16 cells. GRAPHICAL ABSTRACT\",\"PeriodicalId\":15364,\"journal\":{\"name\":\"Journal of Biologically Active Products from Nature\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2022-09-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Biologically Active Products from Nature\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/22311866.2022.2154265\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biologically Active Products from Nature","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/22311866.2022.2154265","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Secondary Metabolites and their Biological Activities from Endophytic Fungal Strain Aspergillus terreus XJA8 Associated with Vernonia anthelmintica
Abstract Two isocoumarins (6-methoxymellein and 6-hydroxymellein), one pyrrole compound (minaline), one lactone derivative (butyrolactone II), five phenolic acids (phenylacetic, veratric (3,4-dimethoxybenzoic), 4-hydroxyphenylacetic, 4-hydroxybenzoic and protocatechuic acid), and two phenolic acid methyl esters ((2-hydroxyphenyl) acetic acid methyl ester and methyl 4-hydroxyphenylacetate), along with 1,3-bis(4-hydroxyphenyl) propan-2-one were isolated from the fungal strain Aspergillus terreus XJA8. The fungal strain was isolated from the root of the medicinal plant Vernonia anthelmintica for first time. All isolated secondary metabolites were evaluated for their antimicrobial activity and melanin synthesis in murine B16 cells. GRAPHICAL ABSTRACT
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