MTHFR C677T多态性与非创伤性股骨头坏死的相关性:一项最新荟萃分析

IF 0.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pteridines Pub Date : 2020-01-01 DOI:10.1515/pteridines-2020-0005
Tao Zhang, Shan Ye, Zhenzhong Chen, Yunmiao Ma
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引用次数: 6

摘要

摘要目的探讨MTHFR C677T多态性与非创伤性股骨头坏死的相关性。方法在cochrane对照试验注册中心、EMBSE和CNKI数据库中对MTHFR C677T多态性和非创伤性股骨头坏死相关的公开发表研究进行电子系统检索。通过比值比(OR)和相应的95%置信区间(95%CI)计算MTHFR C677T多态性与非创伤性股骨头坏死之间的相关性。纳入研究的发表偏倚通过Begg漏斗图和Egger线性回归文本进行评估。结果通过对电子数据库的系统检索,11项原始研究最终纳入本研究。I2检验表明,在纳入的11篇出版物中,存在显著的统计学异质性(I2=53.5%,P=0.018)。调查结果表明,具有CC基因型的高加索人发生非创伤性股骨头坏死的风险降低(OR=0.65,95%CI:0.44-0.96,P=0.031),在美国犹太人和东亚人种中,MTHFR C677T多态性与非创伤性股骨头坏死之间没有相关性(p>0.05)。敏感性分析表明,合并ORs对任何纳入的单一研究都不敏感。Begg漏斗图通常左右对称,这表明没有明显的出版物。Egger线性回归检验也没有显示统计学上的发表偏倚(t=1.57,P=0.15)。结论根据现有证据,MTHFR C677T多态性与非创伤性股骨头坏死相关,尤其是在高加索人种中。具有CC基因型的高加索人种受试者发生非创伤性股骨头坏死的风险降低。
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Association between MTHFR C677T polymorphism and non-traumatic osteonecrosis of the femoral head: An update meta-analysis
Abstract Objective To investigate the correlation between MTHFR C677T polymorphism and non-traumatic osteonecrosis of the femoral head. Methods Open published studies relevant to MTHFR C677T polymorphism and non-traumatic osteonecrosis of the femoral head were electronic systematic searched in the databases of cochrane central register of controlled trials, EMBSE and CNKI. The correlation between MTHFR C677T polymorphism and non-traumatic osteonecrosis of the femoral head was calculated by odds ratio (OR) and corresponding 95% confidence interval (95%CI). The publication bias for the included studies were assessed by Begg’s funnel plot and Egger’s line regression text. Results After systematic searching the electronic databases, 11 original studies were finally included the present work. The I2 test indicated significant statistical heterogeneity (I2=53.5%, P=0.018) across the included 11 publications. The polled results indicated that subjects of Caucasians with CC genotype had decreased risk of developing non-traumatic osteonecrosis of the femoral head (OR=0.65,95%CI: 0.44-0.96, P=0.031). However, there was no correlations between MTHFR C677T polymorphism and non-traumatic osteonecrosis of the femoral head in American Jewish and East Asian races(p>0.05). Sensitivity analysis indicated the pooled ORs were not sensitive to any included single study. The Begg’s funnel plot was generally left and right symmetrical which indicated no obviously publications. The Egger’s line regression test also demonstrated no statistical publication bias (t=1.57, P=0.15). Conclusion According to the present evidence, MTHFR C677T polymorphism was correlated with non-traumatic osteonecrosis of the femoral head especially for Caucasians race. Subjects of Caucasians race with CC genotype had decreased risk of developing non-traumatic osteonecrosis of the femoral head.
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来源期刊
Pteridines
Pteridines 生物-生化与分子生物学
CiteScore
1.20
自引率
25.00%
发文量
6
审稿时长
>12 weeks
期刊介绍: Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.
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