脂质体的医学应用

Biswajit Basu, B. Prajapati, Ayon Dutta, Himanshu Paliwal
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引用次数: 0

摘要

脂质体是一种潜在的药物递送系统,涉及封装到基于磷脂的囊泡载体系统中。与传统的递送系统相比,脂质体可能由于位点特异性靶向、控制释放模式、增强稳定性和降低相关毒性等过程而具有优势。在过去的十年里,一些研究人员试图开发简单或修饰形式的脂质体,用于有效递送各种类型的治疗剂。这篇综述的重点是讨论最近关于脂质体医学应用的一些文献。介绍了不同类型脂质体的作用模式,作为其优越治疗效率的支持基础。讨论了脂质体在递送抗癌、抗菌和抗真菌药物等方面的应用。在讨论的同时,还包括了用于治疗与呼吸和神经系统相关疾病的脂质体载体,并特别强调了当前文献的结果。通过这篇综述收集的信息将有助于提供关于脂质体载体的配方和开发研究现状的想法。
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Medical Application of Liposomes
Liposomes are a potential drug delivery system involving encapsulation into a phospholipid-based vesicular carrier system. In comparison with conventional delivery systems, liposomes may be advantageous due to site-specific targeting, controlled release patterns, enhance stability, and reduce associated toxicity, among other processes. Several researchers in the last decade have attempted to develop simple or modified forms of liposomes for the effective delivery of various types of therapeutic agents. This review is focused on a discussion about some of the recent literature on the medical application of liposomes. An account of the mode of action of different types of liposomes as a supporting basis for their superior therapeutic efficiency was provided. The application of liposomes in the delivery of anticancer, anti-bacterial, and anti-fungal drugs, among others, was discussed. Along with this discussion, liposomal carriers for the management of diseases related to the respiratory and nervous system were included along with a special emphasis on the outcomes of current literature. The information gathered through this review will be useful in furnishing ideas about the current status of research studies conducted on the formulation and development of liposomal carriers.
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