Evaluation of Perioral Skin Rejuvenation with Platelet – Rich Plasma

Introduction:Using Platelet- Rich Plasma (PRP )in aesthetic dermatology has been recently considered and its safety and effectiveness have been widely reported. We conducted this study to evaluate the technique and degree of benefit. Methods: Fifteen (15) patients with different ages, sexes, and facial perioral wrinkles have participated in the current research and received a session of monthly PRP injections (three courses), targeting line and wrinkles in the perioral area. In this study, we have prepared the PRP by using a special test tube and then centrifuge it with relative centrifugal force (RCF) of 1700G for 5 minutes, followed by two minutes of soft centrifugation at room temperature. Results: Mean age ± SD was 40 ± 1.36 years. 44.7% were female. 84.5% of patients are considered adherent (≥ 95% of doses were consumed). Married patients had better adherence (p = 0.04). Age, sex, addiction, imprisonment history, intravenous drug usage were not associated with adherence (p> 0.05). We also extracted previews history of treatment cessation and regimen changes. Efavirenz containing regimens had a higher rate of failure (p =0.001). Conclusion: Wrinkles in perioral area management by PRP injection is an easy technique, with high- quality result and high patient satisfaction, no serious side effects, high patient toleration, and short downtime. Platelet- Rich Plasma can be a competitive substitute for other fillers and revitalization methods in lips and perioral rejuvenation.