功能性神经测量测试结果与贫血、亚临床炎症和内皮功能障碍的血液生物标志物之间的相关性

Renata de Melo Guerra Ribas, Valdenilson Ribeiro Ribas, Diélita Carla Lopes de Oliveira, Marcelo Tavares Viana, Joyce Gomes de Moraes, Hugo André de Lima Martins, C. O. Oliveira Alves, Nery Adamy Neto, Murilo Tolêdo Calafange, Clenes de Oliveira Mendes Calafange, A. Toscano, Raul Manhães de Castro
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引用次数: 0

摘要

引言:功能性神经测量FN评估自主神经系统的功能。目的:评价FN检测结果与贫血、亚临床炎症SI和内皮功能障碍ED的生物标志物之间的相关性。方法:对412例年龄在18-50岁之间的男性患者进行FN和实验室检测。组:对照组(CONT,n=194)和功能障碍组(DYSF,n=218)。FN类别:焦虑控制-(AC)≥75%,压力反射指数-(BRI)≥90%,血液动力学-(HD)≤10%,生理反应-(PR)=31.5 o-32.5 o,以中位数/(最小-最大值)表示。生物标志物:红细胞RBC、血红蛋白、红细胞压积、平均红细胞体积MCV;平均红细胞血红蛋白MCH;平均红细胞血红蛋白浓度MCHC;红细胞分布宽度RDW;总白细胞TL、铁蛋白、转铁蛋白饱和度TS、B12、同型半胱氨酸、C反应蛋白CRP;纤维蛋白原;25-羟基-维生素D3;载脂蛋白A1-Apo-A1;载脂蛋白B-Apo-B;谷草转氨酶GOT;谷丙转氨酶;伽玛GT;上午8点皮质醇;IgE;总胆固醇TC;甘油三酯TG和;高密度脂蛋白HDL和低密度脂蛋白LDL,以频率-[百分比]表达,并通过卡方检验进行分析,p≤0.05*。结果:DYSF显示:AC=24.91/(10.11-69.17)。结论:本研究发现FN检测结果与指示贫血、SI和ED的生物标志物之间存在显著关联。
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Association between functional neurometry test results and blood biomarkers indicative of anaemia, subclinical inflammation, and endothelial dysfunction
Introduction: Functional neurometry-FN assesses the functioning of the autonomic nervous system. Objective: The association between FN test results and the biomarkers of anaemia, subclinical inflammation-SI and endothelial dysfunction-ED was evaluated. Method: 412 male patients aged between 18-50 years were evaluated by FN and Laboratory Testing. Groups: control (CONT, n=194) and dysfunctional (DYSF, n=218). FN categories: Anxiety Control-(AC) ≥75%, Baroreflex Index-(BRI) ≥90%, Hemodynamic- (HD) ≤10% and Physiological response-(PR) =31.5 o -32.5 o , expressed in Median/ (Minimum-Maximum). Biomarkers: red blood cells-RBC, haemoglobin, haematocrit, mean corpuscular volume-MCV; mean corpuscular haemoglobin-MCH; mean corpuscular haemoglobin concentration-MCHC; red cell distribution width-RDW; total leukocytes-TL, ferritin, transferrin saturation-TS, B12, homocysteine, C-reactive protein-CRP; fibrinogen; 25-hydroxy-vitamin-D3; apolipoprotein A1-Apo-A1; apolipoprotein B-Apo-B; glutamic oxalacetic transaminase-GOT; glutamic-pyruvic transaminase-GPT; Gamma GT; 8am cortisol; IgE; total cholesterol-TC; triglycerides-TG, and; high-density lipoprotein-HDL and low-density lipoprotein-LDL, expressed in frequency-[percentage] and analysed by the Chi-square test with p≤0.05*. Results: DYSF presented: AC=24.91/(10.11-69.17), Conclusion: This study found a significant association between FN test results and biomarkers indicative of anaemia, SI and ED.
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