血小板生成素水平与克隆性造血关系的研究进展

国际输血及血液学杂志 Pub Date : 2019-05-20 DOI:10.3760/CMA.J.ISSN.1673-419X.2019.03.016

P. Dong

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引用次数: 0

摘要

最近的基因组研究揭示了许多与血液系统恶性肿瘤相关的体细胞基因突变的存在。这些体细胞突变驱动从单个细胞扩增为可检测的造血克隆。克隆性造血（CH）与年龄相关，并与血液系统恶性肿瘤风险增加有关。血小板生成素（TPO）与细胞表面的c-MPL结合后，可刺激巨核细胞生成、血小板活化和造血干细胞（HSC）维持。越来越多的研究揭示了TPO与CH之间的关系。本文综述了TPO水平与CH之间关系的研究进展，以期为血液系统恶性肿瘤的临床预防、诊断和治疗提供依据。关键词：血小板生成素；造血；突变；血液肿瘤；克隆进化；MPL蛋白，人

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Research progress in relationship between level of thrombopoietin and clonal hematopoiesis

Recent genomic studies have revealed the existence of many somatic gene mutations associated with hematologic malignancies. These somatic mutations drive the expansion from a single cell to a detectable hematopoietic clone. Clonal hematopoiesis (CH) is age-associated and related to increased risk of hematologic malignancy. Thrombopoietin (TPO) stimulates megakaryocytogenesis, platelet activation and hematopoietic stem cell(HSC) maintenance after combining with c-MPL on cell surface. Increasing researches have revealed the relationship between the level of TPO and CH. This article reviews the reasearch progress in the relationship between level of TPO and CH, in order to provide evidences for clinical prevention, diagnosis and treatment of hematologic malignancies. Key words: Thrombopoietin; Hematopoiesis; Mutation; Hematologic neoplasms; Clonal evolution; MPL protein, human

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来源期刊

国际输血及血液学杂志

自引率

0.00%

发文量

10610

期刊介绍： The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.