低密度脂蛋白受体相关蛋白LRP11在肝细胞癌发生中的作用

IF 0.9 4区 材料科学 Science of Advanced Materials Pub Date : 2023-07-01 DOI:10.1166/sam.2023.4501
Jinxian Pei, Huihui Wang, Yan Zhang, Tianshi Chen
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引用次数: 0

摘要

本研究探讨了低密度脂蛋白受体相关蛋白LRP11在肝细胞癌(HCC)中的作用。TCGA和GTEx数据库分析显示,与正常组织相比,癌症组织中LRP11的表达显著增加(P<0.05)。LRP11高表达与癌症患者的生存期较短有关(P<0.01)。沉默LRP11使HepG2细胞活力显著下降(P<0.05),细胞凋亡率升高(P<0.01),凋亡相关蛋白Bax上调(P<01),Bcl-2下调(P<0.001),sh-LRP11组细胞周期S期明显减少(P<0.01),细胞周期蛋白D1表达减少(P>0.01),提示LRP11在癌症组织中高表达,预后不良。LRP11表达的抑制抑制HCC细胞的增殖,促进细胞凋亡,并影响细胞周期进展。这些结果有助于了解HCC发展和进展的分子机制,并确定潜在的治疗靶点。
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The Role of Low-Density Lipoprotein Receptor-Associated Protein LRP11 in the Development of Hepatocellular Carcinoma
This study investigated the role of the low-density lipoprotein receptor-associated protein LRP11 in hepatocellular carcinoma (HCC). Analysis of TCGA and GTEx databases revealed that LRP11 expression was significantly increased in liver cancer tissues compared to normal tissues (P <0.05). High expression of LRP11 was associated with shorter survival in liver cancer patients (P <0.05). Lentivirus transfection was used to create sh-NC and sh-LRP11 groups for further experiments. Silencing LRP11 in HepG2 cells resulted in a significant decrease in cell viability (P <0.05), increased apoptosis rate (P <0.01), and upregulation of the apoptosis-related protein Bax (P <0.01) and downregulation of Bcl-2 (P <0.01). Moreover, the sh-LRP11 group showed a significant decrease in the S-phase of the cell cycle (P <0.01) and reduced expression of Cyclin D1 (P <0.01). These findings indicate that LRP11 is highly expressed in liver cancer tissues and is associated with an unfavorable prognosis. Suppression of LRP11 expression inhibits the proliferation of HCC cells, promotes apoptosis, and affects cell cycle progression. These results contribute to understanding the molecular mechanisms underlying HCC development and progression, as well as identifying potential therapeutic targets.
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来源期刊
Science of Advanced Materials
Science of Advanced Materials NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY
自引率
11.10%
发文量
98
审稿时长
4.4 months
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