The Effect of Pangasius Djambal Gelatin Treatment on the Lymphocyte Cells after Tooth Extraction

Abstract Inflammation is a phase of the wound healing process that occurs after tooth extraction which is influenced by the immune system. Lymphocytes are one type of cell in the immune system that have an important role in the inflammation process. The purpose of this study was to investigate the effect of Pangasius djambal gelatin treatment on the enhancing lymphocyte cell count after tooth extraction in Rattus norvegicus. In this study, the in vivo true experimental laboratories with a post-test group design was maintained. In this study, we performed 3 control groups without treatment by the Pangasius djambal gelatin and 3 treatment groups with 100 mg/mL Pangasius djambal gelatin on the post-extraction wound of the mandibular left lateral incisor of Rattus norvegicus. Each group consists of 5 rats. The lymphocyte cells count in the tooth socket tissue was evaluated on days 3, 5, and 7. The control groups' lymphocyte cells count decreased significantly from 32 to 17.2 from day 3 to day 7. Interestingly, the lymphocyte cells of treatment groups increased from 92.2 to 114.6 from day 3 to day 7. Furthermore, a very strong positive correlation between the observation time and lymphocyte cell count was observed in this work (r = 0.838; very strong). Therefore, the Pangasius djambal gelatin opens new potency to increase the lymphocyte cells count after tooth extraction. Keywords: Pangasius djambal fish, Lymphocytes, Tooth extraction, Intraperitoneal anesthesia