骨髓基质细胞输注治疗急性移植物抗宿主病：原理、数据和未回答的问题

Advances in cell and gene therapy Pub Date : 2018-08-14 DOI:10.1002/acg2.14

Amara Seng, Neil Dunavin

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引用次数: 3

摘要

间充质干细胞/基质细胞输注是治疗类固醇难治性急性移植物抗宿主病（GVHD）的一种很有前途的研究性治疗策略。在此，我们描述了它们在急性移植物抗宿主病中使用的基本原理，迄今为止动物和人类研究报告的临床数据，并强调了最近的研究和调查领域，这些领域为下一代研究的改进提供了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mesenchymal stromal cell infusions for acute graft-versus-host disease: Rationale, data, and unanswered questions

Mesenchymal stem/stromal cells (MSCs) infusions are a promising investigational treatment strategy for steroid-refractory acute graft-versus-host disease (GVHD). Herein we describe the rationale for their use in acute GVHD, the clinical data reported from animal and human studies to date, and we highlight recent areas of research and investigation that provide the basis for improvements in the next generation of studies.

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Advances in cell and gene therapy

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