基于NO、CO和H2S的药物在视觉(眼睛健康)任务中的作用:综述

IF 4.1 3区 化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR Reviews in Inorganic Chemistry Pub Date : 2021-06-08 DOI:10.1515/revic-2021-0009
J. Mir, R. Maurya, Mohd. Washid Khan
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引用次数: 2

摘要

摘要一组定义明确的信号分子负责人类生理的正常功能,包括一氧化氮、一氧化碳和硫化氢,被称为“气体发射器”。由于它们几乎涉及人体的每个系统,使用这些分子作为药物来护理高度敏感的器官是一个非常有趣的研究领域。结合这些有趣的方面,这些气体分子在维持健康眼睛和视力方面的应用方面已成为本综述的目标。在本文中已经讨论了滴管的几个例子,包括NORM(如拉坦前列素和尼普放射性)、CORM(如CORM-3和CORM-A1)以及硫化氢释放系统(如GYY4137)。因此,这三种气体发射器一方面与眼科稳态的关系,另一方面与去感染作用的关系被重点强调。一些能够模拟气体发射器作用的分子系统也被介绍到了主题中。
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NO, CO and H2S based pharmaceuticals in the mission of vision (eye health): a comprehensive review
Abstract A set of well defined signaling molecules responsible for normal functioning of human physiology including nitric oxide along with carbon monoxide and hydrogen sulphide are referred as “gasotransmitters”. Due to their involvement in almost every system of a human body, the care of highly sensitive organs using these molecules as drugs represents highly fascinating area of research. In connection with these interesting aspects, the applied aspects of these gaseous molecules in maintaining healthy eye and vision have been targeted in this review. Several examples of eye-droppers including NORMs like latanoprost and nipradiol, CORMs like CORM-3 and CORM-A1, and Hydrogen sulfide releasing system like GYY4137 have been discussed in this context. Therefore the relation of these trio-gasotransmitters with the ophthalmic homeostasis on one hand, and de-infecting role on the other hand has been mainly highlighted. Some molecular systems capable of mimicking gasotransmitter action have also been introduced in connection with the titled theme.
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来源期刊
Reviews in Inorganic Chemistry
Reviews in Inorganic Chemistry 化学-分析化学
CiteScore
7.30
自引率
4.90%
发文量
20
审稿时长
1 months
期刊介绍: Reviews in Inorganic Chemistry (REVIC) is a quarterly, peer-reviewed journal that focuses on developments in inorganic chemistry. Technical reviews offer detailed synthesis protocols, reviews of methodology and descriptions of apparatus. Topics are treated from a synthetic, theoretical, or analytical perspective. The editors and the publisher are committed to high quality standards and rapid handling of the review and publication process. The journal publishes all aspects of solid-state, molecular and surface chemistry. Topics may be treated from a synthetic, theoretical, or analytical perspective. The editors and the publisher are commited to high quality standards and rapid handling of the review and publication process. Topics: -Main group chemistry- Transition metal chemistry- Coordination chemistry- Organometallic chemistry- Catalysis- Bioinorganic chemistry- Supramolecular chemistry- Ionic liquids
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