各种铬稠杂环的合成方法及其作为抗菌剂的潜力。

IF 1.9 4区 医学 Q3 CHEMISTRY, MEDICINAL Medicinal Chemistry Pub Date : 2024-01-01 DOI:10.2174/0115734064274748231005074100
Neetu Agrawal, Radhika Goswami, Shilpi Pathak
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引用次数: 0

摘要

铬烯是一个重要的杂环化学家族,具有广泛的生物学应用、简单的化学结构和轻微的不良副作用。许多不同的研究团队对通过多种机制表现出意想不到行为的各种色烯类似物的合成进行了研究,从而发现了多种合成途径。此外,不同的铬烯稠合杂环表现出多种迷人的生物学作用,包括抗癌、抗惊厥、抗菌、抗胆碱酯酶、抗结核和抗糖尿病。有鉴于此,本研究的目的是强调许多与铬烯稠合杂环化合物相关的合成技术和抗菌活性。此外,这类研究可以为探索这些化合物在各种疾病领域的其他治疗应用开辟途径,因为它们的生物活性超出了抗菌作用。
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Synthetic Methods for Various Chromeno-fused Heterocycles and their Potential as Antimicrobial Agents.

Chromenes are a significant family of heterocyclic chemicals that have a wide range of biological applications, a simple chemical structure, and only mildly undesirable side effects. The synthesis of a wide range of chromene analogs that displayed unexpected behaviors via numerous mechanisms was investigated by a number of different research teams, which led to the discovery of multiple pathways for their synthesis. In addition, different chromene-fused heterocycles exhibit a wide variety of fascinating biological actions, including those that are anticancer, anticonvulsant, antibacterial, anticholinesterase, antituberculosis, and anti-diabetic. In light of this, the purpose of this study is to highlight the many synthesis techniques and antibacterial activity associated with chromene-fused heterocyclic compounds. Moreover, such research can open avenues for exploring other therapeutic applications of these compounds in various disease areas, as their biological activities extend beyond antibacterial effects.

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来源期刊
Medicinal Chemistry
Medicinal Chemistry 医学-医药化学
CiteScore
4.30
自引率
4.30%
发文量
109
审稿时长
12 months
期刊介绍: Aims & Scope Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.
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