线性百里香的化学特性、杀线虫活性和抗氧化活性。

IF 0.7 4区 医学 Q4 PHARMACOLOGY & PHARMACY Pakistan journal of pharmaceutical sciences Pub Date : 2023-09-01
Rubeena Saleem, Aisha Sana, Yusra Ghani, Faiza Mushtaq, Rubina Abid, Jan Alam, Marium Tariq, Shahnaz Dawar, Razia Sultana, Shaheen Faizi
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引用次数: 0

摘要

线性胸腺及其精油(EO)在传统医学中被用于治疗一系列疾病。线性百里香EO的GC-MS分析显示存在六十四种成分。胸腺素(50.62%)、香芹酚(13.23%)、醋酸香芹醇(7.72%),-双月桂烯(5.47%)和邻辛烯(5.43%)是油中仅有的五种基本成分,占油的82.07%。与其他化合物相比,EO及其主要成分百里酚和香芹酚在爪哇根结线虫中的死亡率最高。Carvacrol也被证明有助于抑制M.javanica卵的孵化。这是首次对T.linearis EO及其成分龙脑和石竹烯的杀线虫作用进行研究。使用ABTS自由基清除法评估EO组分和活性化合物的抗氧化活性。胸腺素和香芹酚具有较高的抗氧化活性。百里酚和香芹酚的IC50分别为38.18克/毫升和49.65克/毫升,与阳性对照特洛氧(47.12克/毫升)相当。结果清楚地表明,EO及其成分、百里酚和香芹酚作为杀线虫剂和抗氧化剂具有很高的效力。
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Chemical characterization, nematicidal and antioxidant activities of Thymus linearis Benth.

Thymus linearis and its essential oil (EO) are used to cure a range of diseases in traditional medicine. GC-MS analysis of Thymus linearis EO revealed the presence of sixty-four components. Thymol (50.62%), carvacrol (13.23 %), carvacrol acetate (7.72%), -bisabolene (5.47%) and o-cymene (5.47%) are the only five basic constituents in the oil which accounts for 82.07% of oil. When compared to other compounds, the EO and its primary components thymol and carvacrol had the largest proportion of mortality in Meloidogyne javanica. Carvacrol has also been proven to be helpful in suppressing the hatching of M. javanica eggs. This is the first time T. linearis EO and its constituents, such as borneol and caryophyllene, have been studied for nematicidal action. The antioxidant activity of EO components and active compounds was assessed using the ABTS radical scavenging method. Thymol and carvacrol were found to exhibit high antioxidant activity. The IC50 of thymol and carvacrol are found to be 38.18 g/ml and 49.65 g/ml, respectively and are comparable to the positive control trolox (47.12 g/ml). Results clearly showed high potency for EO and its constituents, thymol and carvacrol as nematicidal and antioxidant agents.

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来源期刊
CiteScore
1.40
自引率
12.50%
发文量
211
审稿时长
4.5 months
期刊介绍: Pakistan Journal of Pharmaceutical Sciences (PJPS) is a peer reviewed multi-disciplinary pharmaceutical sciences journal. The PJPS had its origin in 1988 from the Faculty of Pharmacy, University of Karachi as a biannual journal, frequency converted as quarterly in 2005, and now PJPS is being published as bi-monthly from January 2013. PJPS covers Biological, Pharmaceutical and Medicinal Research (Drug Delivery, Pharmacy Management, Molecular Biology, Biochemical, Pharmacology, Pharmacokinetics, Phytochemical, Bio-analytical, Therapeutics, Biotechnology and research on nano particles.
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