非侵入性蜂蜜细胞CSRR葡萄糖传感器:设计考虑和建模

IF 5.6 4区 医学 Q1 ENGINEERING, BIOMEDICAL Irbm Pub Date : 2023-02-01 DOI:10.1016/j.irbm.2022.04.002
K. Abdesselam , C. Hannachi , R. Shahbaz , F. Deshours , G. Alquie , H. Kokabi , A. Omer , J.-M. Davaine
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引用次数: 4

摘要

多年来,微波技术已经证明了它们对生物组织进行表征的能力。这项研究旨在采用这种方法来研究手指葡萄糖水平的变化,并开发一种糖尿病患者可以使用的敏感传感器。材料和方法开发了一个简化的人类指尖四层组织模型,以验证传感器检测葡萄糖水平变化的能力。对将人类指尖插入传感区域同时改变压力的传感器进行了三维电磁模拟,并使用VNA(矢量网络分析仪)将其与获得的实验结果进行了比较。结果当独立改变手指层厚度时,观察到皮肤层厚度的变化对频率的影响最大。还注意到,手指压力越高,共振越倾向于低频,幅度越小。结论实验结果显示了手指压力对传感器的影响。进一步的研究正在进行中,以使用对糖尿病受试者的最佳拟合压力方案来获得实验结果的良好再现性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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A Non-Invasive Honey-Cell CSRR Glucose Sensor: Design Considerations and Modelling

Objective

Over the years, microwave techniques have demonstrated their ability to characterise biological tissues. This study aimed to employ this approach to investigate the changes in the finger's glucose levels and to develop a sensitive sensor that people with diabetes can use.

Materials and methods

A simplified four-layer tissue model of the human fingertip was developed to validate the sensor's ability to detect variations in glucose levels. 3D electromagnetic simulations of the sensor with human fingertips inserted in the sensing region while varying the pressure were performed and compared to obtained experimental results using a VNA (vector network analyser).

Results

When varying the finger layers thicknesses independently, it was observed that the change in the skin layer thickness influences the frequency the most. It was also noticed that the higher the finger pressure, the more the resonance shifted towards low frequencies with a decreasing magnitude.

Conclusion

The achieved results show the impact of the finger's pressure on the sensor. Further investigations are in progress to obtain a good reproducibility of experimental results using a best-fitted pressure protocol on diabetic subjects.

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来源期刊
Irbm
Irbm ENGINEERING, BIOMEDICAL-
CiteScore
10.30
自引率
4.20%
发文量
81
审稿时长
57 days
期刊介绍: IRBM is the journal of the AGBM (Alliance for engineering in Biology an Medicine / Alliance pour le génie biologique et médical) and the SFGBM (BioMedical Engineering French Society / Société française de génie biologique médical) and the AFIB (French Association of Biomedical Engineers / Association française des ingénieurs biomédicaux). As a vehicle of information and knowledge in the field of biomedical technologies, IRBM is devoted to fundamental as well as clinical research. Biomedical engineering and use of new technologies are the cornerstones of IRBM, providing authors and users with the latest information. Its six issues per year propose reviews (state-of-the-art and current knowledge), original articles directed at fundamental research and articles focusing on biomedical engineering. All articles are submitted to peer reviewers acting as guarantors for IRBM''s scientific and medical content. The field covered by IRBM includes all the discipline of Biomedical engineering. Thereby, the type of papers published include those that cover the technological and methodological development in: -Physiological and Biological Signal processing (EEG, MEG, ECG…)- Medical Image processing- Biomechanics- Biomaterials- Medical Physics- Biophysics- Physiological and Biological Sensors- Information technologies in healthcare- Disability research- Computational physiology- …
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