髓系/淋巴肿瘤伴ZMYM2: FGFR1重排:复杂的三代表型和克隆进化与相关的基因组改变

IF 0.7 Q4 HEMATOLOGY Leukemia Research Reports Pub Date : 2023-01-01 DOI:10.1016/j.lrr.2023.100370
Dong Chen , Guang Liu , Michael R. Lewis , Xia Li , Matthew Ulrickson , Rajneesh Nath , Weina Chen
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引用次数: 0

摘要

我们报告一例髓系/淋巴肿瘤伴ZMYM2::FGFR1重排(MLNZMYM2::FGFR1),表现出复杂的疾病演变。该肿瘤最初表现为淋巴结t淋巴母细胞淋巴瘤(t - lbl)和骨髓嗜酸性粒细胞增多的骨髓增生性肿瘤(MPN),然后转变为系统性肥大细胞增多症(SM),可能伴有额外的JAK3和其他突变,最后转化为急性髓性白血病(AML),伴有额外的/继发性遗传异常(21号染色体获得,der(13)t(8;13)和RUNX1突变)。据我们所知,这是MLNZMYM2::FGFR1具有复杂的三系/表型[t细胞(T-LBL),肥大细胞(SM)和髓细胞(MPN和AML)]谱系进化的第一例。
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Myeloid/lymphoid neoplasm with ZMYM2::FGFR1 rearrangement: A complex trilineage phenotypic and clonal evolution with associated genomic alterations

We report a case of myeloid/lymphoid neoplasm with ZMYM2::FGFR1 rearrangement (MLNZMYM2::FGFR1) exhibiting a complex disease evolution. This neoplasm initially presented as T-lymphoblastic lymphoma (T-LBL) in lymph node and myeloproliferative neoplasm (MPN) with eosinophilia in bone marrow, then transitioned to systemic mastocytosis (SM) likely accompanied by additional JAK3 and other mutations and finally transformed to acute myeloid leukemia (AML) accompanied by additional/secondary genetic abnormality (gain of chromosome 21, der(13)t(8;13), and RUNX1 mutation). To our knowledge, this is the first case of MLNZMYM2::FGFR1 with a complex trilineage/phenotypic [T-cell (T-LBL), mast cell (SM), and myeloid (MPN and AML)] lineage evolution.

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来源期刊
Leukemia Research Reports
Leukemia Research Reports Medicine-Oncology
CiteScore
1.70
自引率
0.00%
发文量
70
审稿时长
23 weeks
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