铜的获取和解毒机制在二态真菌中是保守的

IF 5.7 2区 生物学 Q1 MYCOLOGY Fungal Biology Reviews Pub Date : 2023-01-01 DOI:10.1016/j.fbr.2022.11.004
Dayane Moraes , Jackeliny Garcia Costa Rodrigues , Marielle Garcia Silva , Lucas Weba Soares , Célia Maria de Almeida Soares , Alexandre Melo Bailão , Mirelle Garcia Silva-Bailão
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引用次数: 1

摘要

病原真菌在附着和侵入宿主后能否存活取决于其获取营养物质的能力,包括过渡金属铜,由于其氧化还原电位,铜具有多种结构和催化功能。虽然这种离子是必需的,但过量时是有毒的。在感染过程中,宿主操纵铜水平以控制感染,微生物可能受到金属剥夺或中毒。铜稳态是由膜转运蛋白和其他受特定转录因子调节的蛋白质维持的,在酵母模型酿酒酵母以及曲霉属、念珠菌属和隐球菌属的致病物种中都有很好的描述。然而,热二态真菌对铜可利用性的稳态和适应性反应方面的研究仍然很少,并且最近已有的研究很少出现在文献中。在这篇综述中,我们试图总结已经在人类致病真菌中描述的铜稳态的机制,此外,通过硅分析研究这些机制在二态真菌中的保护作用。
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Copper acquisition and detoxification machineries are conserved in dimorphic fungi
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来源期刊
CiteScore
10.60
自引率
0.00%
发文量
36
期刊介绍: Fungal Biology Reviews is an international reviews journal, owned by the British Mycological Society. Its objective is to provide a forum for high quality review articles within fungal biology. It covers all fields of fungal biology, whether fundamental or applied, including fungal diversity, ecology, evolution, physiology and ecophysiology, biochemistry, genetics and molecular biology, cell biology, interactions (symbiosis, pathogenesis etc), environmental aspects, biotechnology and taxonomy. It considers aspects of all organisms historically or recently recognized as fungi, including lichen-fungi, microsporidia, oomycetes, slime moulds, stramenopiles, and yeasts.
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