Peiqing Wang , Jiajia Wang , Fatma M. El-Demerdash , Jinfeng Wei
{"title":"芦花中的混凝剂成分。","authors":"Peiqing Wang , Jiajia Wang , Fatma M. El-Demerdash , Jinfeng Wei","doi":"10.1016/j.jfutfo.2023.02.003","DOIUrl":null,"url":null,"abstract":"<div><p><em>Rubia cordifolia</em> L. belongs to Rubiaceae family. Its medicinal parts are mainly root and rhizome, which is included in the <em>Chinese Pharmacopoeia</em> (2020), has the effect of cooling blood and stopping bleeding, removing stasis and channeling menstruation. However, studies on the hemostatic effect of <em>R. cordifolia</em> mainly focus on extracts, and the hemostatic components are less studied. Therefore, chemical constituents and coagulant activity of <em>R. cordifolia</em> were investigated in this paper. Eleven compounds were isolated and identified from <em>R. cordifolia</em>, including 1-hydroxy-2-methyl-9,10-anthraquinone (<strong>1</strong>), 1,4-dihydroxy-2-methylanthraquinone (<strong>2</strong>), palmitic acid (<strong>3</strong>), tricosanoic acid (<strong>4</strong>), <em>ω</em>-hydroxypachybasin (<strong>5</strong>), ursolic acid (<strong>6</strong>), oleanolic acid (<strong>7</strong>), rubilactone (<strong>8</strong>), <em>β</em>-sitosterol (<strong>9</strong>), cordifoliol (<strong>10</strong>), 1,3-dihydroxy-2-ethoxymethyl-9,10-anthraquinone (<strong>11</strong>). <em>ω</em>-Hydroxypachybasin was isolated from <em>Rubia</em> genus for the first time. 1,4-Dihydroxy-2-methylanthraquinone, rubilactone and 1,3-dihydroxy-2-ethoxymethyl-9,10-anthraquinone could remarkably shorten the plasma calcium coating time <em>in vitro</em>, thus indicating that they had procoagulant activity.</p></div>","PeriodicalId":100784,"journal":{"name":"Journal of Future Foods","volume":"3 3","pages":"Pages 220-224"},"PeriodicalIF":5.2000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Coagulant compounds in Rubia cordifolia L.\",\"authors\":\"Peiqing Wang , Jiajia Wang , Fatma M. El-Demerdash , Jinfeng Wei\",\"doi\":\"10.1016/j.jfutfo.2023.02.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><em>Rubia cordifolia</em> L. belongs to Rubiaceae family. Its medicinal parts are mainly root and rhizome, which is included in the <em>Chinese Pharmacopoeia</em> (2020), has the effect of cooling blood and stopping bleeding, removing stasis and channeling menstruation. However, studies on the hemostatic effect of <em>R. cordifolia</em> mainly focus on extracts, and the hemostatic components are less studied. Therefore, chemical constituents and coagulant activity of <em>R. cordifolia</em> were investigated in this paper. Eleven compounds were isolated and identified from <em>R. cordifolia</em>, including 1-hydroxy-2-methyl-9,10-anthraquinone (<strong>1</strong>), 1,4-dihydroxy-2-methylanthraquinone (<strong>2</strong>), palmitic acid (<strong>3</strong>), tricosanoic acid (<strong>4</strong>), <em>ω</em>-hydroxypachybasin (<strong>5</strong>), ursolic acid (<strong>6</strong>), oleanolic acid (<strong>7</strong>), rubilactone (<strong>8</strong>), <em>β</em>-sitosterol (<strong>9</strong>), cordifoliol (<strong>10</strong>), 1,3-dihydroxy-2-ethoxymethyl-9,10-anthraquinone (<strong>11</strong>). <em>ω</em>-Hydroxypachybasin was isolated from <em>Rubia</em> genus for the first time. 1,4-Dihydroxy-2-methylanthraquinone, rubilactone and 1,3-dihydroxy-2-ethoxymethyl-9,10-anthraquinone could remarkably shorten the plasma calcium coating time <em>in vitro</em>, thus indicating that they had procoagulant activity.</p></div>\",\"PeriodicalId\":100784,\"journal\":{\"name\":\"Journal of Future Foods\",\"volume\":\"3 3\",\"pages\":\"Pages 220-224\"},\"PeriodicalIF\":5.2000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Future Foods\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S277256692300006X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Future Foods","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S277256692300006X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Rubia cordifolia L. belongs to Rubiaceae family. Its medicinal parts are mainly root and rhizome, which is included in the Chinese Pharmacopoeia (2020), has the effect of cooling blood and stopping bleeding, removing stasis and channeling menstruation. However, studies on the hemostatic effect of R. cordifolia mainly focus on extracts, and the hemostatic components are less studied. Therefore, chemical constituents and coagulant activity of R. cordifolia were investigated in this paper. Eleven compounds were isolated and identified from R. cordifolia, including 1-hydroxy-2-methyl-9,10-anthraquinone (1), 1,4-dihydroxy-2-methylanthraquinone (2), palmitic acid (3), tricosanoic acid (4), ω-hydroxypachybasin (5), ursolic acid (6), oleanolic acid (7), rubilactone (8), β-sitosterol (9), cordifoliol (10), 1,3-dihydroxy-2-ethoxymethyl-9,10-anthraquinone (11). ω-Hydroxypachybasin was isolated from Rubia genus for the first time. 1,4-Dihydroxy-2-methylanthraquinone, rubilactone and 1,3-dihydroxy-2-ethoxymethyl-9,10-anthraquinone could remarkably shorten the plasma calcium coating time in vitro, thus indicating that they had procoagulant activity.
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