原发性大弥散性B细胞淋巴瘤放疗和免疫化疗的保守治疗:罕见实体的诊断和治疗

IF 0.1 Q4 OBSTETRICS & GYNECOLOGY Clinica e Investigacion en Ginecologia y Obstetricia Pub Date : 2023-07-01 DOI:10.1016/j.gine.2023.100857
J.F. Robles Díaz
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引用次数: 0

摘要

引言原发性宫颈恶性淋巴瘤是一种非常罕见的疾病,仅占所有宫颈肿瘤的0.008%,占所有女性结外淋巴瘤的2%。主要症状和/或临床发现一例来自秘鲁安第斯山脉的66岁妇女,其发病期为4个月,以女性腐蚀症为特征,宫颈有5厘米的肿瘤。用免疫组织化学方法对宫颈活检进行淋巴瘤和鳞状细胞癌的鉴别。原发性诊断宫颈原发性弥漫性大B细胞淋巴瘤,采用Ann Arbor IE IPI低风险分期。治疗干预和结果通过免疫化疗(利妥昔单抗、环磷酰胺、阿霉素、长春新碱和泼尼松)进行治疗,然后用特殊的IMRT技术在15个疗程内进行3000 cGy剂量的巩固性外部放射治疗。结果得到了令人满意的疾病控制,并且没有放射并发症。结论原发性宫颈弥漫性大B细胞淋巴瘤非常罕见,因此,在原发性子宫颈间质病变的病例中,应考虑淋巴瘤的怀疑。
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Manejo conservador con radioterapia e inmunoquimioterapia en el linfoma difuso de células B grandes primario de cuello uterino: Diagnóstico y tratamiento de una entidad rara

Introduction

Primary malignant cervical lymphoma is a very rare disease, which represents only 0.008% of all cervical tumors and 2% of all female extranodal lymphomas.

Main symptoms and/or clinical findings

The case of a 66-year-old woman from the Peruvian Andes is presented, with a disease period of 4 months characterized by gynaecorrhagia, with evidence of a 5 cm tumor cervix. Immunohistochemistry was performed on the biopsy of cervix to differentiate lymphoma from squamous cell carcinoma.

Primary diagnosis

Primary diffuse large B-cell lymphoma of the cervix with Ann Arbor IE IPI low-risk staging.

Therapeutic interventions and results

She being managed with immunochemotherapy (rituximab, cyclophosphamide, adriamycin, vincristine and prednisone), followed by consolidative external radiotherapy at a dose of 3,000 cGy in 15 sessions with a special IMRT technique. Resulting in satisfactory disease control and no complications from irradiation.

Conclusion

Primary diffuse large B-cell lymphoma of the cervix is very rare, therefore, in a case of primary stromal lesion of the cervix, suspicion of lymphoma should be taken into account.

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来源期刊
CiteScore
0.20
自引率
0.00%
发文量
54
期刊介绍: Una excelente publicación para mantenerse al día en los temas de máximo interés de la ginecología de vanguardia. Resulta idónea tanto para el especialista en ginecología, como en obstetricia o en pediatría, y está presente en los más prestigiosos índices de referencia en medicina.
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