乔治·欧内斯特·罗杰斯1927-2021

IF 0.2 4区 哲学 Q4 HISTORY & PHILOSOPHY OF SCIENCE Historical Records of Australian Science Pub Date : 2023-06-22 DOI:10.1071/hr23004
Racheline (Lynn) Rogers
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引用次数: 0

摘要

1977年,乔治·罗杰斯(1927-2021)因其在角蛋白分子结构和角化生物化学方面的杰出贡献被选为英国皇家科学院院士。他是将电子显微镜应用于头发和羊毛超微结构以及毛囊超微结构的先驱。他发现角蛋白中的瓜氨酸,以及转谷氨酰胺酶和肽精氨酸脱亚胺酶(PAD)的酶、作用和组织化学定位。他于1965年首次证明了核糖体依赖性角蛋白合成,随后对头发角蛋白的生物合成进行了详细的研究。他的研究开启了对羽毛毛囊发育过程中的分子事件的研究,后来导致了羽毛和相关鸟类角蛋白聚集基因的克隆和表征。他还克隆并鉴定了三类羊毛角蛋白的基因,并研究了角蛋白基因的转录。1977年,他被阿德莱德大学授予科学博士学位,以表彰他的工作。2013年,他被授予澳大利亚军官勋章。
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George Ernest Rogers 1927–2021

George Rogers (1927–2021) was elected to Fellowship of the Academy in 1977 for his outstanding contributions to our knowledge of the molecular structure of keratins and the biochemistry of keratinisation. He was a pioneer in the application of electron microscopy to hair and wool ultrastructure and to that of the hair follicle. He discovered citrulline in keratin proteins, and the enzymes, roles, and histochemical localisation of transglutaminase and peptidylarginine deiminase (PAD). He was the first to demonstrate ribosomal-dependent keratin protein synthesis in 1965 followed by detailed studies of the biosynthesis of hair keratin proteins. His research initiated studies on the molecular events in the development of the feather follicle and later led to the cloning and characterisation of the clustered genes of feather and related avian keratins. He also cloned and characterised genes for the three classes of wool keratin proteins and studied the transcription of keratin genes. In 1977, he was awarded a DSc by the University of Adelaide in recognition for his work. In 2013, he was made an Officer in the Order of Australia.

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来源期刊
Historical Records of Australian Science
Historical Records of Australian Science HISTORY & PHILOSOPHY OF SCIENCE-
CiteScore
0.90
自引率
66.70%
发文量
22
期刊介绍: Historical Records of Australian Science is a bi-annual journal that publishes two kinds of unsolicited manuscripts relating to the history of science, pure and applied, in Australia, New Zealand and the southwest Pacific. Historical Articles–original scholarly pieces of peer-reviewed research Historical Documents–either hitherto unpublished or obscurely published primary sources, along with a peer-reviewed scholarly introduction. The first issue of the journal (under the title Records of the Australian Academy of Science), appeared in 1966, and the current name was adopted in 1980.
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