慢性鼻窦炎生物膜中宿主与微生物的相互作用及研究模型

IF 5.9 Q1 MICROBIOLOGY Biofilm Pub Date : 2023-09-29 DOI:10.1016/j.bioflm.2023.100160
Emily J. Vanderpool , Kendra P. Rumbaugh
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引用次数: 0

摘要

慢性鼻窦炎(CRS)是一种以鼻窦长期炎症为特征的衰弱性疾病。它影响了相当一部分人口,给个人和医疗系统带来了相当大的负担。CRS的发病机制是多因素的,细菌感染在CRS的发展和持续中起着至关重要的作用。近年来,生物膜的存在已成为鼻窦炎慢性病的关键因素,使治疗进一步复杂化并加剧症状。这篇综述旨在探讨生物膜在CRS中的作用,重点是金黄色葡萄球菌和铜绿假单胞菌的参与,它们在慢性感染中的相互作用,以及研究CRS中生物膜的模型系统。这些物种是微生物相互作用如何影响疾病进展的一个例子,并说明CRS研究需要继续调查和创新。
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Host-microbe interactions in chronic rhinosinusitis biofilms and models for investigation

Chronic rhinosinusitis (CRS) is a debilitating condition characterized by long-lasting inflammation of the paranasal sinuses. It affects a significant portion of the population, causing a considerable burden on individuals and healthcare systems. The pathogenesis of CRS is multifactorial, with bacterial infections playing a crucial role in CRS development and persistence. In recent years, the presence of biofilms has emerged as a key contributor to the chronicity of sinusitis, further complicating treatment and exacerbating symptoms. This review aims to explore the role of biofilms in CRS, focusing on the involvement of the bacterial species Staphylococcus aureus and Pseudomonas aeruginosa, their interactions in chronic infections, and model systems for studying biofilms in CRS. These species serve as an example of how microbial interplay can influence disease progression and exemplify the need for continued investigation and innovation in CRS research.

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来源期刊
Biofilm
Biofilm MICROBIOLOGY-
CiteScore
7.50
自引率
1.50%
发文量
30
审稿时长
57 days
期刊介绍:
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