帕金森病的生物标志物：最新进展

Q2 Medicine Biomarkers in Neuropsychiatry Pub Date : 2023-09-09 DOI:10.1016/j.bionps.2023.100074

Kyla Y. Yamashita , Sweta Bhoopatiraju , Bret D. Silverglate , George T. Grossberg

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引用次数: 0

摘要

帕金森病的生物标志物在神经心理学领域得到了广泛的研究。尽管帕金森病是临床诊断的，但生物标志物被证明是一种很有前途的手段，可以在早期识别疾病，跟踪疾病进展，并将帕金森病与路易体痴呆等其他疾病区分开来。帕金森病生物标志物的临床效用水平存在争议。这篇最新综述讨论了寻找帕金森病生物标志物的最新进展，并深入研究了每种生物标记物的临床价值，探索了通过脑脊液、血清、遗传学和成像等不同方式获得的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biomarkers in Parkinson’s disease: A state of the art review

Biomarkers in Parkinson’s disease are widely researched in the field of neuropsychiatry. Though Parkinson’s disease is diagnosed clinically, biomarkers prove to be a promising means to identify disease in early stages, track disease progression, and distinguish Parkinson’s disease from other conditions like dementia with Lewy bodies. There is debate on the level of clinical utility specific Parkinson’s disease biomarkers have. This state of the art review discusses recent advances in the search for Parkinson’s disease biomarkers and delves into the clinical value of each, exploring biomarkers obtained through different modalities like cerebrospinal fluid, serum, genetics and imaging.

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